Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SRC | P12931 | 8/20 | 0.45 |
| ▸ | NR3C1 | P04150 | 1/20 | 0.44 |
| ▸ | YES1 | P07947 | 3/20 | 0.43 |
| ▸ | FGR | P09769 | 3/20 | 0.43 |
| ▸ | KDR | P35968 | 4/20 | 0.42 |
| ▸ | PIK3CD | O00329 | 3/20 | 0.42 |
| ▸ | PIK3CA | P42336 | 3/20 | 0.42 |
| ▸ | PIK3CB | P42338 | 3/20 | 0.42 |
| ▸ | PIK3CG | P48736 | 3/20 | 0.42 |
| ▸ | PRKDC | P78527 | 3/20 | 0.42 |
| ▸ | ABL1 | P00519 | 3/20 | 0.42 |
| ▸ | EGFR | P00533 | 2/20 | 0.42 |
| ▸ | HCK | P08631 | 2/20 | 0.42 |
| ▸ | MTOR | P42345 | 2/20 | 0.42 |
| ▸ | EPHB4 | P54760 | 2/20 | 0.42 |
| ▸ | PI4KB | Q9UBF8 | 2/20 | 0.42 |
| ▸ | RET | P07949 | 4/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | TP53 | P04637 | 1/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24096870 | 0.85 | SRC (0.45) | SRCYES1FGRKDRPIK3CD | |
| SCHEMBL10261070 | 0.81 | SRC (0.52) | SRCYES1FGRKDRPIK3CD | |
| SCHEMBL12551792 | 0.80 | SRC (0.64) | SRCPIK3CDPIK3CAPIK3CBPIK3CG | |
| SCHEMBL10261498 | 0.79 | PIK3CD (0.53) | SRCYES1FGRKDRPIK3CD | |
| SCHEMBL25113285 | 0.79 | RET (0.43) | SRCYES1FGRKDRPIK3CD | |
| SCHEMBL13019881 | 0.78 | CYP1A2 (0.67) | SRCYES1FGRKDRPIK3CD | |
| SCHEMBL19476294 | 0.77 | RET (0.48) | SRCYES1FGRKDRPIK3CD | |
| SCHEMBL24072615 | 0.75 | SRC (0.43) | SRCFGFR1JAK2JAK3LCK | |
| SCHEMBL17406901 | 0.75 | MAPK1 (0.57) | EGFRKDM4ECYP1A2CYP3A4MAPK1 | |
| SCHEMBL12551793 | 0.74 | PIK3CD (0.61) | SRCKDRPIK3CDPIK3CAPIK3CB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2021252488-A1 | INHIBITORS OF NEK7 KINASE | Halia Therapeutics, Inc. (US) | 2021-12-16 | — | — | WO | disclosed |