Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RET | P07949 | 2/20 | 0.43 |
| ▸ | HDAC1 | Q13547 | 3/20 | 0.43 |
| ▸ | SRC | P12931 | 7/20 | 0.43 |
| ▸ | YES1 | P07947 | 3/20 | 0.43 |
| ▸ | FGR | P09769 | 3/20 | 0.43 |
| ▸ | MTOR | P42345 | 3/20 | 0.42 |
| ▸ | PIK3CD | O00329 | 3/20 | 0.42 |
| ▸ | PIK3CA | P42336 | 3/20 | 0.42 |
| ▸ | PIK3CB | P42338 | 3/20 | 0.42 |
| ▸ | PIK3CG | P48736 | 3/20 | 0.42 |
| ▸ | PRKDC | P78527 | 3/20 | 0.42 |
| ▸ | ABL1 | P00519 | 3/20 | 0.42 |
| ▸ | EGFR | P00533 | 3/20 | 0.42 |
| ▸ | HCK | P08631 | 2/20 | 0.42 |
| ▸ | KDR | P35968 | 2/20 | 0.42 |
| ▸ | EPHB4 | P54760 | 2/20 | 0.42 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | TP53 | P04637 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30404896 | 0.84 | ADK (0.46) | RETHDAC1SRCMTORPIK3CD | |
| SCHEMBL20553120 | 0.84 | ADK (0.46) | RETHDAC1SRCMTORPIK3CD | |
| SCHEMBL10261070 | 0.81 | SRC (0.52) | RETHDAC1SRCYES1FGR | |
| SCHEMBL10261498 | 0.79 | PIK3CD (0.53) | RETSRCYES1FGRMTOR | |
| SCHEMBL24096871 | 0.79 | SRC (0.45) | RETSRCYES1FGRMTOR | |
| SCHEMBL29677976 | 0.78 | SRC (0.65) | SRCMTORPIK3CDPIK3CAPIK3CB | |
| SCHEMBL25678139 | 0.75 | MTOR (0.49) | RETHDAC1SRCYES1FGR | |
| SCHEMBL21028946 | 0.74 | PIK3CD (0.55) | SRCYES1FGRMTORPIK3CD | |
| SCHEMBL22215343 | 0.74 | PIK3CD (0.55) | RETSRCYES1FGRMTOR | |
| SCHEMBL26148251 | 0.74 | MAPK1 (0.42) | RETSRCYES1FGRMTOR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4234031-A2 | C40-, C28-, AND C-32-LINKED RAPAMYCIN ANALOGS AS MTOR INHIBITORS | Revolution Medicines, Inc. (US) | 2023-08-30 | — | — | EP | disclosed |
| EP-3788049-B1 | C40-, C28-, AND C-32-LINKED RAPAMYCIN ANALOGS AS MTOR INHIBITORS | REVOLUTION MEDICINES INC (US) | 2023-03-29 | — | — | EP | disclosed |