Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TP53 | P04637 | 2/20 | 0.33 |
| ▸ | MAPT | P10636 | 2/20 | 0.33 |
| ▸ | FFAR4 | Q5NUL3 | 1/20 | 0.33 |
| ▸ | POLB | P06746 | 1/20 | 0.33 |
| ▸ | NAPRT | Q6XQN6 | 1/20 | 0.33 |
| ▸ | PPARG | P37231 | 1/20 | 0.32 |
| ▸ | DHODH | Q02127 | 4/20 | 0.32 |
| ▸ | GSK3B | P49841 | 1/20 | 0.32 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.32 |
| ▸ | TACR1 | P25103 | 1/20 | 0.31 |
| ▸ | GPBAR1 | Q8TDU6 | 1/20 | 0.31 |
| ▸ | LMNA | P02545 | 1/20 | 0.31 |
| ▸ | PKM | P14618 | 1/20 | 0.31 |
| ▸ | CALCRL | Q16602 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2411262 | 0.85 | PLCG1 (0.35) | TP53MAPTPOLB | |
| SCHEMBL5008198 | 0.83 | TACR1 (0.38) | MAPTFFAR4NAPRTPPARGTACR1 | |
| SCHEMBL4430058 | 0.82 | PTGER2 (0.32) | — | |
| SCHEMBL1156835 | 0.80 | SOAT1 (0.39) | LMNA | |
| SCHEMBL1156852 | 0.80 | SOAT1 (0.37) | — | |
| SCHEMBL1830980 | 0.79 | NAPRT (0.33) | FFAR4POLBNAPRTDHODHDYRK1A | |
| SCHEMBL1157178 | 0.78 | LMNA (0.35) | PPARGLMNAPKM | |
| SCHEMBL2409767 | 0.77 | HTR2C (0.38) | FFAR4GSK3BTACR1 | |
| SCHEMBL3645629 | 0.75 | DHODH (0.36) | FFAR4NAPRTDHODHGSK3BDYRK1A | |
| SCHEMBL2409764 | 0.74 | DYRK1A (0.36) | FFAR4NAPRTPPARGDHODHGSK3B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2364979-A1 | Pyrrole compounds | Takeda Pharmaceutical Company Limited (JP) | 2011-09-14 | — | — | EP | disclosed |
| EP-2114917-A2 | PYRROLE COMPOUNDS | Takeda Pharmaceutical Company Limited (JP) | 2009-11-11 | — | — | EP | disclosed |
| WO-2008108380-A2 | PYRROLE COMPOUNDS | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2008-09-12 | — | — | WO | disclosed |