Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 12/20 | 0.68 |
| ▸ | TP53 | P04637 | 12/20 | 0.64 |
| ▸ | RXFP1 | Q9HBX9 | 2/20 | 0.64 |
| ▸ | POLB | P06746 | 3/20 | 0.64 |
| ▸ | LMNA | P02545 | 4/20 | 0.63 |
| ▸ | THRB | P10828 | 1/20 | 0.60 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24098814 | 0.87 | MAPT (0.54) | MAPTTP53RXFP1POLBLMNA | |
| SCHEMBL24121221 | 0.87 | MAPT (0.54) | MAPTTP53RXFP1POLBLMNA | |
| SCHEMBL30363070 | 0.87 | MAPT (0.54) | MAPTTP53RXFP1POLBLMNA | |
| SCHEMBL24098896 | 0.83 | MEN1 (0.68) | MAPTTP53RXFP1POLBLMNA | |
| SCHEMBL30362937 | 0.83 | MAPT (0.51) | MAPTTP53RXFP1POLBLMNA | |
| SCHEMBL24121184 | 0.83 | RXFP1 (0.57) | MAPTTP53RXFP1POLB | |
| SCHEMBL11512747 | 0.82 | KDM4E (0.57) | MAPT | |
| SCHEMBL24121186 | 0.81 | TP53 (0.77) | MAPTTP53RXFP1POLBLMNA | |
| SCHEMBL24098884 | 0.79 | MAPT (0.83) | MAPTTP53RXFP1POLBLMNA | |
| SCHEMBL9110471 | 0.79 | MEN1 (0.56) | MAPTTP53RXFP1POLBLMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20210393812-A1 | HETEROCYCLIC COMPOUNDS AND IMAGING AGENTS FOR IMAGING HUNTINGTIN PROTEIN | CHDI FOUNDATION, INC. | 2021-12-23 | — | — | US | disclosed |
| WO-2021252775-A1 | HETEROCYCLIC COMPOUNDS AND IMAGING AGENTS FOR IMAGING HUNTINGTIN PROTEIN | CHDI FOUNDATION, INC. (US) | 2021-12-16 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20210393812-A1 | HETEROCYCLIC COMPOUNDS AND IMAGING AGENTS FOR IMAGING HUNTINGTIN PROTEIN | HTT, HYPK, HSPBP1 | MAPT 9/4885TP53 142/4885RXFP1 2280/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.