Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 2/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
| ▸ | HTT | P42858 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.44 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.43 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.43 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.43 |
| ▸ | OPRL1 | P41146 | 1/20 | 0.43 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.38 |
| ▸ | TP53 | P04637 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.35 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.35 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.35 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.34 |
| ▸ | AKR1C2 | P52895 | 1/20 | 0.34 |
| ▸ | CCR5 | P51681 | 1/20 | 0.33 |
| ▸ | SLC6A2 | P23975 | 2/20 | 0.33 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23458475 | 1.00 | LMNA (0.44) | LMNAMEN1HTTKMT2ASMN1; SMN2 | |
| SCHEMBL23182622 | 1.00 | LMNA (0.44) | LMNAMEN1HTTKMT2ASMN1; SMN2 | |
| SCHEMBL29771571 | 1.00 | LMNA (0.44) | LMNAMEN1HTTKMT2ASMN1; SMN2 | |
| Hydrochloric Acid SCHEMBL28638820 | 0.99 | LMNA (0.43) | LMNAMEN1HTTKMT2ASMN1; SMN2 | |
| Hydrochloric Acid SCHEMBL28638822 | 0.99 | LMNA (0.43) | LMNAMEN1HTTKMT2ASMN1; SMN2 | |
| SCHEMBL25871719 | 0.88 | GAA (0.41) | MEN1KMT2AGAAL3MBTL1TP53 | |
| SCHEMBL23486089 | 0.80 | TP53 (0.46) | LMNAMEN1HTTKMT2ASMN1; SMN2 | |
| SCHEMBL22078042 | 0.80 | TP53 (0.46) | LMNAMEN1HTTKMT2ASMN1; SMN2 | |
| SCHEMBL24811011 | 0.79 | ACACA (0.39) | LMNAHTTKMT2AGAAL3MBTL1 | |
| SCHEMBL29771538 | 0.79 | ACACA (0.39) | LMNAHTTKMT2AGAAL3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2021252669-A1 | CRF1 RECEPTOR ANTAGONIST FOR THE TREATMENT OF CONGENITAL ADRENAL HYPERPLASIA | NEUROCRINE BIOSCIENCES, INC. (US) | 2021-12-16 | — | — | WO | disclosed |