Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC6 | Q9UBN7 | 8/20 | 0.67 |
| ▸ | HDAC1 | Q13547 | 7/20 | 0.49 |
| ▸ | HDAC8 | Q9BY41 | 2/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.42 |
| ▸ | HPGD | P15428 | 1/20 | 0.42 |
| ▸ | RAB9A | P51151 | 1/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.42 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.42 |
| ▸ | RECQL | P46063 | 1/20 | 0.42 |
| ▸ | ADAM17 | P78536 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
| ▸ | ABL1 | P00519 | 2/20 | 0.42 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
| ▸ | ERCC1 | P07992 | 1/20 | 0.40 |
| ▸ | ERCC4 | Q92889 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2410147 | 0.99 | HDAC6 (0.64) | HDAC6HDAC1HDAC8ALDH1A1HPGD | |
| SCHEMBL2411097 | 0.76 | HDAC6 (0.67) | HDAC6HDAC1HDAC8ALDH1A1HPGD | |
| SCHEMBL2408211 | 0.76 | EPHX2 (0.48) | HDAC6HDAC1HDAC8ALDH1A1LMNA | |
| SCHEMBL2413536 | 0.75 | HDAC6 (0.56) | HDAC6HDAC1HDAC8ALDH1A1HPGD | |
| SCHEMBL2407826 | 0.73 | POLB (0.70) | HDAC6HDAC1HDAC8ALDH1A1HPGD | |
| SCHEMBL2406624 | 0.73 | POLB (0.70) | HDAC6HDAC1HDAC8ALDH1A1HPGD | |
| SCHEMBL2412018 | 0.71 | POLB (0.72) | HDAC6HDAC1HDAC8HPGDLMNA | |
| SCHEMBL2407120 | 0.71 | HDAC1 (0.57) | HDAC6HDAC1HDAC8ALDH1A1HPGD | |
| SCHEMBL2407873 | 0.71 | HDAC1 (0.57) | HDAC6HDAC1HDAC8ALDH1A1HPGD | |
| SCHEMBL6919015 | 0.70 | HDAC6 (0.62) | HDAC6HDAC1HDAC8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011106632-A1 | SUBSTITUTED HYDROXAMIC ACIDS AND USES THEREOF | MILLENNIUM PHARMACEUTICALS, INC. (US) | 2011-09-01 | — | — | WO | disclosed |