Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC6 | Q9UBN7 | 12/20 | 0.67 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.55 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.55 |
| ▸ | HDAC1 | Q13547 | 8/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.48 |
| ▸ | HPGD | P15428 | 1/20 | 0.48 |
| ▸ | RAB9A | P51151 | 1/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.45 |
| ▸ | MEN1 | O00255 | 1/20 | 0.45 |
| ▸ | LMNA | P02545 | 1/20 | 0.45 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.45 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.45 |
| ▸ | RECQL | P46063 | 1/20 | 0.45 |
| ▸ | ADAM17 | P78536 | 1/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.45 |
| ▸ | HDAC8 | Q9BY41 | 3/20 | 0.45 |
| ▸ | HDAC3 | O15379 | 2/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2409971 | 0.76 | HDAC6 (0.67) | HDAC6HDAC1ALDH1A1HPGDRAB9A | |
| SCHEMBL2475381 | 0.75 | HDAC6 (0.52) | HDAC6HDAC1ALDH1A1HPGDMEN1 | |
| SCHEMBL2410147 | 0.74 | HDAC6 (0.64) | HDAC6HDAC1ALDH1A1HPGDRAB9A | |
| SCHEMBL2415976 | 0.72 | HDAC6 (0.49) | HDAC6HDAC1HDAC8HDAC3 | |
| SCHEMBL2408848 | 0.71 | TSHR (0.67) | HDAC6SMN1; SMN2HDAC1ALDH1A1HPGD | |
| SCHEMBL14454655 | 0.70 | HDAC6 (0.60) | HDAC6HDAC1HDAC8HDAC3 | |
| SCHEMBL2410201 | 0.70 | HDAC6 (0.52) | HDAC6SMN1; SMN2HDAC1ALDH1A1HPGD | |
| SCHEMBL2410188 | 0.70 | HDAC6 (0.44) | HDAC6SMN1; SMN2HDAC1HPGDRAB9A | |
| SCHEMBL25735895 | 0.70 | HDAC6 (0.66) | HDAC6SMN1; SMN2ALDH1A1HPGDRAB9A | |
| SCHEMBL2407908 | 0.69 | LMNA (0.55) | HDAC6HDAC1LMNAHDAC8HDAC3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011106632-A1 | SUBSTITUTED HYDROXAMIC ACIDS AND USES THEREOF | MILLENNIUM PHARMACEUTICALS, INC. (US) | 2011-09-01 | — | — | WO | disclosed |