Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.45 |
| ▸ | SIRT6 | Q8N6T7 | 1/20 | 0.45 |
| ▸ | TPMT | P51580 | 1/20 | 0.43 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
| ▸ | GPR35 | Q9HC97 | 1/20 | 0.42 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.42 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.42 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.42 |
| ▸ | FLT1 | P17948 | 1/20 | 0.42 |
| ▸ | FGFR3 | P22607 | 1/20 | 0.42 |
| ▸ | KDR | P35968 | 1/20 | 0.42 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.41 |
| ▸ | ERN1 | O75460 | 1/20 | 0.41 |
| ▸ | VCAM1 | P19320 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | G6PD | P11413 | 1/20 | 0.40 |
| ▸ | CRHBP | P24387 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12565695 | 0.86 | TPMT (0.51) | TPMTTDP1MEN1KMT2AGPR35 | |
| SCHEMBL27883380 | 0.85 | SIRT6 (0.48) | SMN1; SMN2SIRT6TDP1MEN1KMT2A | |
| SCHEMBL6211358 | 0.83 | SIRT6 (0.46) | SMN1; SMN2SIRT6TDP1MEN1KMT2A | |
| SCHEMBL647368 | 0.83 | SMN1; SMN2 (0.47) | SMN1; SMN2SIRT6TDP1MEN1KMT2A | |
| SCHEMBL7363915 | 0.81 | SMN1; SMN2 (0.53) | SMN1; SMN2SIRT6TPMTTDP1MEN1 | |
| SCHEMBL15122867 | 0.81 | SIRT6 (0.45) | SMN1; SMN2SIRT6TDP1MEN1KMT2A | |
| SCHEMBL24100061 | 0.81 | TDP1 (0.48) | SIRT6TDP1MEN1KMT2AGPR35 | |
| SCHEMBL4995662 | 0.81 | SMN1; SMN2 (0.46) | SMN1; SMN2SIRT6TDP1MEN1KMT2A | |
| SCHEMBL16974729 | 0.80 | TDP1 (0.47) | SMN1; SMN2SIRT6TDP1MEN1KMT2A | |
| SCHEMBL1126945 | 0.79 | TSHR (0.53) | SMN1; SMN2TDP1MEN1KMT2ALMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3922247-A1 | 15-PGDH INHIBITOR | Kyorin Pharmaceutical Co., Ltd. (JP) | 2021-12-15 | — | — | EP | disclosed |