Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE5A | O76074 | 5/20 | 0.53 |
| ▸ | PDE1A | P54750 | 2/20 | 0.53 |
| ▸ | PDE1B | Q01064 | 2/20 | 0.53 |
| ▸ | PDE1C | Q14123 | 2/20 | 0.53 |
| ▸ | MEN1 | O00255 | 4/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.46 |
| ▸ | NPC1 | O15118 | 4/20 | 0.46 |
| ▸ | RAB9A | P51151 | 4/20 | 0.46 |
| ▸ | PKM | P14618 | 1/20 | 0.46 |
| ▸ | SLC12A2 | P55011 | 1/20 | 0.46 |
| ▸ | SLC12A5 | Q9H2X9 | 1/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.46 |
| ▸ | HPGD | P15428 | 1/20 | 0.46 |
| ▸ | CCNK | O75909 | 2/20 | 0.45 |
| ▸ | DDB1 | Q16531 | 2/20 | 0.45 |
| ▸ | CDK12 | Q9NYV4 | 2/20 | 0.45 |
| ▸ | TP53 | P04637 | 1/20 | 0.45 |
| ▸ | MAPT | P10636 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24101407 | 0.85 | CCNK (0.51) | PDE5APDE1APDE1BPDE1CMEN1 | |
| SCHEMBL24101425 | 0.68 | CCNK (0.66) | PDE5AMEN1KMT2ANPC1RAB9A | |
| SCHEMBL24101681 | 0.68 | PDE5A (0.70) | PDE5APDE1APDE1BPDE1CMEN1 | |
| SCHEMBL24101687 | 0.68 | LCK (0.52) | PDE5AKDM4ENPC1RAB9ASMN1; SMN2 | |
| SCHEMBL5490457 | 0.68 | SMN1; SMN2 (0.52) | PDE5AMEN1KMT2ANPC1RAB9A | |
| SCHEMBL5480830 | 0.67 | ALDH1A1 (0.49) | PDE5APDE1APDE1BPDE1CMEN1 | |
| SCHEMBL24101625 | 0.67 | CCNK (0.78) | PDE5APDE1APDE1BPDE1CMEN1 | |
| SCHEMBL25720783 | 0.67 | NPC1 (0.69) | PDE5APDE1APDE1BPDE1CMEN1 | |
| SCHEMBL24101707 | 0.66 | CCNK (0.67) | PDE5APDE1APDE1BPDE1CMEN1 | |
| SCHEMBL5481091 | 0.66 | CCNE1 (0.69) | PDE5APDE1APDE1BPDE1CMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2021249517-A1 | A MOLECULAR GLUE REGULATING CDK12-DDB1 INTERACTION TO TRIGGER CYCLIN K DEGRADATION | NATIONAL INSTITUTE OF BIOLOGICAL SCIENCES, BEIJING (CN) | 2021-12-16 | — | — | WO | disclosed |