Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PPARG | P37231 | 14/20 | 0.84 |
| ▸ | CYP1A2 | P05177 | 3/20 | 0.83 |
| ▸ | MAPT | P10636 | 3/20 | 0.83 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.83 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.83 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.83 |
| ▸ | PMP22 | Q01453 | 2/20 | 0.83 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.83 |
| ▸ | GLA | P06280 | 1/20 | 0.83 |
| ▸ | TSHR | P16473 | 1/20 | 0.83 |
| ▸ | EDNRA | P25101 | 1/20 | 0.83 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.83 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.83 |
| ▸ | RXRA | P19793 | 6/20 | 0.74 |
| ▸ | PTGS2 | P35354 | 2/20 | 0.71 |
| ▸ | EGFR | P00533 | 1/20 | 0.71 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.71 |
| ▸ | DRD1 | P21728 | 1/20 | 0.71 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.71 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.71 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30095195 | 1.00 | PPARG (0.84) | PPARGCYP1A2MAPTMAPK1TDP1 | |
| SCHEMBL30913371 | 0.92 | CYP1A2 (0.74) | PPARGCYP1A2MAPTMAPK1TDP1 | |
| Exisulind SCHEMBL4776597 | 0.91 | CYP1A2 (1.00) | PPARGCYP1A2MAPTMAPK1TDP1 | |
| Exisulind SCHEMBL25371 | 0.91 | CYP1A2 (1.00) | PPARGCYP1A2MAPTMAPK1TDP1 | |
| Exisulind SCHEMBL29395528 | 0.91 | CYP1A2 (1.00) | PPARGCYP1A2MAPTMAPK1TDP1 | |
| Exisulind SCHEMBL1651133 | 0.91 | CYP1A2 (1.00) | PPARGCYP1A2MAPTMAPK1TDP1 | |
| SCHEMBL30913530 | 0.91 | PPARG (0.74) | PPARGCYP1A2MAPTMAPK1TDP1 | |
| Exisulind SCHEMBL9711060 | 0.90 | CYP1A2 (0.98) | PPARGCYP1A2MAPTMAPK1TDP1 | |
| SCHEMBL8521006 | 0.90 | CYP1A2 (0.82) | PPARGCYP1A2MAPTMAPK1TDP1 | |
| Exisulind SCHEMBL7634644 | 0.90 | CYP1A2 (0.98) | PPARGCYP1A2MAPTMAPK1TDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20230234909-A1 | INDENE COMPOUNDS, PHARMACEUTICAL COMPOSITIONS THEREOF, AND THEIR THERAPEUTIC APPLICATIONS | NUCMITO PHARMACEUTICALS CO. LTD. (CN) | 2023-07-27 | — | — | US | claimed |
| CN-116472034-A | Indene compound, pharmaceutical composition thereof and therapeutic application thereof | 藤济(厦门)生物医药科技有限公司 | 2023-07-21 | — | — | CN | claimed |
| CN-117916215-A | Indene compound, pharmaceutical composition thereof and therapeutic application thereof | 藤济(厦门)生物医药科技有限公司 | 2024-04-19 | — | — | CN | disclosed |
| US-20240116845-A1 | INDENE COMPOUNDS, PHARMACEUTICAL COMPOSITIONS THEREOF, AND THEIR THERAPEUTIC APPLICATIONS | NUCMITO PHARMACEUTICALS CO LTD (CN) | 2024-04-11 | — | — | US | disclosed |
| US-20230234909-A1 | INDENE COMPOUNDS, PHARMACEUTICAL COMPOSITIONS THEREOF, AND THEIR THERAPEUTIC APPLICATIONS | NUCMITO PHARMACEUTICALS CO. LTD. (CN) | 2023-07-27 | — | — | US | disclosed |
| US-20230234909-A1 | INDENE COMPOUNDS, PHARMACEUTICAL COMPOSITIONS THEREOF, AND THEIR THERAPEUTIC APPLICATIONS | NUCMITO PHARMACEUTICALS CO. LTD. (CN) | 2023-07-27 | — | — | US | disclosed |
| US-20230234909-A1 | INDENE COMPOUNDS, PHARMACEUTICAL COMPOSITIONS THEREOF, AND THEIR THERAPEUTIC APPLICATIONS | NUCMITO PHARMACEUTICALS CO. LTD. (CN) | 2023-07-27 | — | — | US | disclosed |
| CN-116472034-A | Indene compound, pharmaceutical composition thereof and therapeutic application thereof | 藤济(厦门)生物医药科技有限公司 | 2023-07-21 | — | — | CN | disclosed |
| WO-2021249529-A1 | INDENE COMPOUNDS, PHARMACEUTICAL COMPOSITIONS THEREOF, AND THEIR THERAPEUTIC APPLICATIONS | NUCMITO PHARMACEUTICALS CO., LTD. (CN) | 2021-12-16 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20230234909-A1 | INDENE COMPOUNDS, PHARMACEUTICAL COMPOSITIONS THEREOF, AND THEIR THERAPEUTIC APPLICATIONS | MMP1, IDO1, COL1A1 | PPARG 378/4885CYP1A2 24/4885MAPT 1585/4885 |
| US-20240116845-A1 | INDENE COMPOUNDS, PHARMACEUTICAL COMPOSITIONS THEREOF, AND THEIR THERAPEUTIC APPLICATIONS | MMP1, IDO1, COL1A1 | PPARG 378/4885CYP1A2 24/4885MAPT 1585/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.