Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK8 | P45983 | 8/20 | 0.50 |
| ▸ | MAPK9 | P45984 | 5/20 | 0.50 |
| ▸ | MAPK10 | P53779 | 3/20 | 0.49 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.46 |
| ▸ | ACACB | O00763 | 3/20 | 0.44 |
| ▸ | JUN | P05412 | 1/20 | 0.42 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.42 |
| ▸ | ADORA2B | P29275 | 1/20 | 0.42 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.42 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.41 |
| ▸ | AXL | P30530 | 2/20 | 0.40 |
| ▸ | TYRO3 | Q06418 | 2/20 | 0.40 |
| ▸ | MERTK | Q12866 | 2/20 | 0.40 |
| ▸ | GSK3A | P49840 | 1/20 | 0.40 |
| ▸ | GSK3B | P49841 | 1/20 | 0.40 |
| ▸ | RIPK2 | O43353 | 1/20 | 0.40 |
| ▸ | FLT3 | P36888 | 1/20 | 0.40 |
| ▸ | GAS6 | Q14393 | 1/20 | 0.40 |
| ▸ | EGFR | P00533 | 1/20 | 0.40 |
| ▸ | INSR | P06213 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18084601 | 0.91 | MAPK1 (0.49) | MAPK8MAPK9MAPK10MAPK1ACACB | |
| SCHEMBL24104434 | 0.84 | KDM4E (0.53) | MAPK8MAPK9MAPK10MAPK1ACACB | |
| SCHEMBL31736934 | 0.80 | MAPK8 (0.49) | MAPK8MAPK1ACACBMERTK | |
| SCHEMBL19117546 | 0.80 | MAPK1 (0.68) | MAPK8MAPK9MAPK10MAPK1ACACB | |
| SCHEMBL24104377 | 0.80 | MAPK8 (0.47) | MAPK8MAPK9MAPK10MAPK1JUN | |
| SCHEMBL16039970 | 0.77 | MAPK8 (0.49) | MAPK8MAPK9MAPK10MAPK1JUN | |
| SCHEMBL11099362 | 0.77 | MAPK8 (0.49) | MAPK8MAPK9MAPK10MAPK1JUN | |
| SCHEMBL16039969 | 0.77 | MAPK8 (0.49) | MAPK8MAPK9MAPK10MAPK1JUN | |
| SCHEMBL31056972 | 0.77 | EGFR (0.49) | MAPK8MAPK9MAPK10MAPK1JUN | |
| SCHEMBL25950523 | 0.77 | MAPK8 (0.50) | MAPK8MAPK9MAPK10MAPK1JUN |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2021250399-A1 | 4-ETHYNYLPYRIDINE DERIVATIVES USEFUL AS GCN2 INHIBITORS | IP2IPO INNOVATIONS LIMITED (GB) | 2021-12-16 | — | — | WO | disclosed |