Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 1/20 | 0.49 |
| ▸ | INSR | P06213 | 1/20 | 0.49 |
| ▸ | LCK | P06239 | 1/20 | 0.49 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.49 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.49 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.46 |
| ▸ | MAPK8 | P45983 | 6/20 | 0.46 |
| ▸ | MAPK10 | P53779 | 4/20 | 0.46 |
| ▸ | MAPK9 | P45984 | 4/20 | 0.44 |
| ▸ | FYN | P06241 | 1/20 | 0.44 |
| ▸ | TYRO3 | Q06418 | 5/20 | 0.43 |
| ▸ | MERTK | Q12866 | 5/20 | 0.43 |
| ▸ | FLT3 | P36888 | 4/20 | 0.43 |
| ▸ | GAS6 | Q14393 | 4/20 | 0.43 |
| ▸ | AXL | P30530 | 3/20 | 0.43 |
| ▸ | JUN | P05412 | 1/20 | 0.42 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.42 |
| ▸ | ADORA2B | P29275 | 1/20 | 0.42 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.42 |
| ▸ | HPGDS | O60760 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31057007 | 0.78 | MAPK8 (0.42) | EGFRINSRLCKPDGFRBPDGFRA | |
| SCHEMBL558853 | 0.78 | HPGDS (0.56) | EGFRINSRLCKPDGFRBPDGFRA | |
| SCHEMBL558852 | 0.78 | HPGDS (0.56) | EGFRINSRLCKPDGFRBPDGFRA | |
| SCHEMBL22241896 | 0.78 | MAPK6 (0.56) | MAPK1MAPK8MAPK10 | |
| SCHEMBL16039970 | 0.77 | MAPK8 (0.49) | MAPK1MAPK8MAPK10MAPK9TYRO3 | |
| SCHEMBL16039969 | 0.77 | MAPK8 (0.49) | MAPK1MAPK8MAPK10MAPK9TYRO3 | |
| SCHEMBL11099362 | 0.77 | MAPK8 (0.49) | MAPK1MAPK8MAPK10MAPK9TYRO3 | |
| SCHEMBL24104403 | 0.77 | MAPK8 (0.50) | EGFRINSRLCKPDGFRBPDGFRA | |
| SCHEMBL25950523 | 0.77 | MAPK8 (0.50) | EGFRINSRLCKPDGFRBPDGFRA | |
| SCHEMBL17730226 | 0.74 | KDM4E (0.64) | EGFRINSRLCKPDGFRAMAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20240246960-A1 | 7-Morpholino-L,6-Naphthyridin-5-yl Derivatives and Pharmaceutical Compositions Thereof Useful as DNA-PK Inhibitor | PROVINCIAL HEALTH SERVICES AUTHORITY (CA) | 2024-07-25 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20240246960-A1 | 7-Morpholino-L,6-Naphthyridin-5-yl Derivatives and Pharmaceutical Compositions Thereof Useful as DNA-PK Inhibitor | DCK, ERCC2, POLK | EGFR 2330/4885INSR 4324/4885LCK 2313/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.