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SCHEMBL24112088

SCHEMBL24112088

CCN(CCN(C)C)CCN(C)C(=O)c1ccc(Nc2nccn3c(-c4ccc(OC)c(F)c4F)cnc23)cc1Cl

nearest known ligand 0.41

Predicted protein targets (top 10)

geneUniProtsupporting neighboursconfidence
▸ PTK6 Q13882 4/20 0.41
▸ IGF1R P08069 1/20 0.36
▸ FGFR3 P22607 2/20 0.36
▸ CSF1R P07333 1/20 0.34
▸ EGFR P00533 8/20 0.34
▸ KDR P35968 4/20 0.33
▸ ERBB2 P04626 2/20 0.33
▸ LCK P06239 2/20 0.33
▸ AURKB Q96GD4 1/20 0.33
▸ MCHR1 Q99705 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL24112346 0.92 PTK6 (0.39) PTK6IGF1RFGFR3EGFRERBB2
SCHEMBL30171783 0.85 PTK6 (0.50) PTK6FGFR3EGFRLCKAURKB
SCHEMBL22123240 0.85 PTK6 (0.50) PTK6FGFR3EGFRLCKAURKB
SCHEMBL25450694 0.84 PTK6 (0.40) PTK6IGF1REGFRLCKAURKB
SCHEMBL30385212 0.83 PTK6 (0.50) PTK6LCKAURKB
SCHEMBL22123969 0.83 PTK6 (0.48) PTK6IGF1REGFRLCKAURKB
SCHEMBL30385303 0.83 PTK6 (0.48) PTK6IGF1REGFRLCKAURKB
SCHEMBL22123581 0.83 PTK6 (0.41) PTK6IGF1RLCKAURKB
SCHEMBL22139113 0.82 PTK6 (0.48) PTK6CSF1RKDRLCKAURKB
SCHEMBL30172107 0.82 PTK6 (0.48) PTK6CSF1RKDRLCKAURKB

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2021249896-A1 NOVEL IMIDAZOPYRAZINE DERIVATIVES F. HOFFMANN-LA ROCHE AG (CH) 2021-12-16 — — WO disclosed
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