K-252A

K-252A

SCHEMBL24112155

COC(=O)C1(O)CC2O[C@]1(C)n1c3ccccc3c3c4c(c5c6ccccc6n2c5c31)C(=O)NC4

nearest known ligand 1.00 ✓ in ChEMBL — recovers established targets

Full drug profile on Sugi Atlas →

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
NTRK1 P04629 9/20 1.00
PRKCQ Q04759 6/20 1.00
KDR P35968 6/20 1.00
MAP3K11 Q16584 6/20 1.00
MAP3K9 P80192 5/20 1.00
PRKD3 O94806 4/20 1.00
PRKCG P05129 4/20 1.00
PRKCB P05771 4/20 1.00
PRKCA P17252 4/20 1.00
PRKCH P24723 4/20 1.00
PRKCI P41743 4/20 1.00
PRKCE Q02156 4/20 1.00
PRKCZ Q05513 4/20 1.00
PRKCD Q05655 4/20 1.00
PRKD1 Q15139 4/20 1.00
MAP3K10 Q02779 4/20 1.00
MYLK Q15746 3/20 1.00
CDK4 P11802 2/20 1.00
CDK2 P24941 2/20 1.00
CAMKK2 Q96RR4 2/20 1.00

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
K-252A SCHEMBL29434956 1.00 NTRK1 (1.00) NTRK1PRKCQKDRMAP3K11MAP3K9
K-252A SCHEMBL13993461 1.00 NTRK1 (1.00) NTRK1PRKCQKDRMAP3K11MAP3K9
K-252A SCHEMBL31181849 1.00 NTRK1 (1.00) NTRK1PRKCQKDRMAP3K11MAP3K9
K-252A SCHEMBL29355962 1.00 NTRK1 (1.00) NTRK1PRKCQKDRMAP3K11MAP3K9
K-252A SCHEMBL13485248 1.00 NTRK1 (1.00) NTRK1PRKCQKDRMAP3K11MAP3K9
K-252A SCHEMBL15575821 1.00 NTRK1 (1.00) NTRK1PRKCQKDRMAP3K11MAP3K9
K-252A SCHEMBL13787898 1.00 NTRK1 (1.00) NTRK1PRKCQKDRMAP3K11MAP3K9
K-252A SCHEMBL968886 1.00 NTRK1 (1.00) NTRK1PRKCQKDRMAP3K11MAP3K9
K-252A SCHEMBL32665760 1.00 NTRK1 (1.00) NTRK1PRKCQKDRMAP3K11MAP3K9
K-252A SCHEMBL29660621 1.00 NTRK1 (1.00) NTRK1PRKCQKDRMAP3K11MAP3K9

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2021252490-A2 USE OF HEAT SHOCK PROTEIN INHIBITORS FOR THE TREATMENT OF NEURODEVELOPMENTAL DISORDERS THE CHILDREN'S MEDICAL CENTER CORPORATION (US) 2021-12-16 WO disclosed