K-252A

K-252A

SCHEMBL29355962

COC(=O)[C@@]1(O)C[C@H]2O[C@]1(C)n1c3ccccc3c3c4c(c5c6ccccc6n2c5c31)C(=O)NC4

nearest known ligand 1.00 ✓ in ChEMBL — recovers established targets

Full drug profile on Sugi Atlas →

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
NTRK1 P04629 9/20 1.00
PRKCQ Q04759 6/20 1.00
KDR P35968 6/20 1.00
MAP3K11 Q16584 6/20 1.00
MAP3K9 P80192 5/20 1.00
PRKD3 O94806 4/20 1.00
PRKCG P05129 4/20 1.00
PRKCB P05771 4/20 1.00
PRKCA P17252 4/20 1.00
PRKCH P24723 4/20 1.00
PRKCI P41743 4/20 1.00
PRKCE Q02156 4/20 1.00
PRKCZ Q05513 4/20 1.00
PRKCD Q05655 4/20 1.00
PRKD1 Q15139 4/20 1.00
MAP3K10 Q02779 4/20 1.00
MYLK Q15746 3/20 1.00
CDK4 P11802 2/20 1.00
CDK2 P24941 2/20 1.00
CAMKK2 Q96RR4 2/20 1.00

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
K-252A SCHEMBL29434956 1.00 NTRK1 (1.00) NTRK1PRKCQKDRMAP3K11MAP3K9
K-252A SCHEMBL13993461 1.00 NTRK1 (1.00) NTRK1PRKCQKDRMAP3K11MAP3K9
K-252A SCHEMBL31181849 1.00 NTRK1 (1.00) NTRK1PRKCQKDRMAP3K11MAP3K9
K-252A SCHEMBL13485248 1.00 NTRK1 (1.00) NTRK1PRKCQKDRMAP3K11MAP3K9
K-252A SCHEMBL15575821 1.00 NTRK1 (1.00) NTRK1PRKCQKDRMAP3K11MAP3K9
K-252A SCHEMBL24112155 1.00 NTRK1 (1.00) NTRK1PRKCQKDRMAP3K11MAP3K9
K-252A SCHEMBL13787898 1.00 NTRK1 (1.00) NTRK1PRKCQKDRMAP3K11MAP3K9
K-252A SCHEMBL968886 1.00 NTRK1 (1.00) NTRK1PRKCQKDRMAP3K11MAP3K9
K-252A SCHEMBL32665760 1.00 NTRK1 (1.00) NTRK1PRKCQKDRMAP3K11MAP3K9
K-252A SCHEMBL29660621 1.00 NTRK1 (1.00) NTRK1PRKCQKDRMAP3K11MAP3K9

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 545 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-4735586-A1 CELLULAR REPROGRAMMING Samuel, Amy Jane (NZ) 2026-05-06 EP claimed
EP-4713433-A2 LIVER ORGANOIDS WITH INTRAHEPATIC SYMPATHETIC NERVES, AND METHODS OF USE THEREOF Children's Hospital Medical Center (US) 2026-03-25 EP claimed
EP-4709377-A2 METHODS OF TREATMENT AND DIAGNOSIS OF PARKINSON'S DISEASE ASSOCIATED WITH WILD-TYPE LRRK2 Neuron23, Inc. (US) 2026-03-18 EP claimed
EP-4680973-A1 PROTEOMIC RISK SCORE FOR OSTEOARTHRITIS (OA) Regeneron Pharmaceuticals, Inc. (US) 2026-01-21 EP claimed
US-20260011407-A1 PREDICTIVE BIOMARKERS AND USE THEREOF TO TREAT PARKINSON'S DISEASE NEURON23 INC (US) 2026-01-08 US claimed
US-12472259-B2 PKC inhibitors for the treatment of septic cholestasis with polymethine dye targeting SMARTDYELIVERY GMBH (DE) 2025-11-18 US claimed
EP-4633630-A1 TREATMENT OF CANCER RESISTANT TO EGFR TKI USING C-MET INHIBITOR Apollomics Inc. (US) 2025-10-22 EP claimed
WO-2025216949-A1 METHODS FOR TREATING A TUMOR WITH ANTI-CDH6 ANTIBODY DRUG CONJUGATES ONCUSP THERAPEUTICS, INC. (US) 2025-10-16 WO claimed
US-20250268913-A1 PKC INHIBITORS FOR THE TREATMENT OF SEPTIC CHOLESTASIS WITH CTM TARGETING SMARTDYELIVERY GMBH (DE) 2025-08-28 US claimed
WO-2025120106-A1 METHODS FOR ISOLATING EMBRYONIC STEM CELLS FROM AN AVIAN EMBRYO CELLS SUPRÊME (FR) 2025-06-12 WO claimed
WO-2022226168-A1 DIAGNOSTIC AND TREATMENT OF CANCER USING C-MET INHIBITOR APOLLOMICS INC. (US) 2022-10-27 WO claimed
EP-4073516-A1 METHODS OF TREATING CANCER PATIENTS WITH RAS NODE OR RTK TARGETED THERAPEUTIC AGENTS Celcuity Inc. (US) 2022-10-19 EP claimed
CN-110468051-B K252A fermentation medium and preparation method thereof 海正药业(杭州)有限公司 2022-08-23 CN claimed
US-20220249509-A1 METHOD FOR PREVENTING HAIR LOSS ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI (US) 2022-08-11 US claimed
US-20220252603-A1 METHOD FOR TREATING CANCER PATIENTS USING C-MET INHIBITOR APOLLOMICS INC. (HANGZHOU) (CN) 2022-08-11 US claimed
US-11390922-B2 C-CBL mutations and uses thereof UNIVERSITY OF CHICAGO (US) 2022-07-19 US claimed
CN-114599978-A Methods of treating cancer patients using C-MET inhibitors 浙江冠科美博生物科技有限公司 2022-06-07 CN claimed
EP-3993764-A1 METHOD FOR PREVENTING HAIR LOSS Icahn School of Medicine at Mount Sinai (US) 2022-05-11 EP claimed
WO-2022093685-A1 METHODS OF TREATMENT AND DIAGNOSIS OF PARKINSON'S DISEASE ASSOCIATED WITH WILD-TYPE LRRK2 NEURON23, INC. (US) 2022-05-05 WO claimed
EP-3980783-A1 METHOD FOR TREATING CANCER PATIENTS USING C-MET INHIBITOR Apollomics Inc. (Hangzhou) (CN) 2022-04-13 EP claimed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20260011407-A1 PREDICTIVE BIOMARKERS AND USE THEREOF TO TREAT PARKINSON'S DISEASE LRRK2, PARK7, BMP2K NTRK1 202/4885PRKCQ 831/4885KDR 1874/4885
US-12472259-B2 PKC inhibitors for the treatment of septic cholestasis with polymethine dye targeting PRKCH, PRKCZ, PIKFYVE NTRK1 4490/4885PRKCQ 7/4885KDR 680/4885
US-20220249509-A1 METHOD FOR PREVENTING HAIR LOSS MYLK3, MYLK4, MYLK NTRK1 2344/4885PRKCQ 716/4885KDR 3964/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.