Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALOX15 | P16050 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 4/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.36 |
| ▸ | NPC1 | O15118 | 2/20 | 0.36 |
| ▸ | RAB9A | P51151 | 2/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | TP53 | P04637 | 1/20 | 0.36 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.36 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.36 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.36 |
| ▸ | PKM | P14618 | 1/20 | 0.36 |
| ▸ | HPGD | P15428 | 1/20 | 0.36 |
| ▸ | TSHR | P16473 | 1/20 | 0.36 |
| ▸ | APEX1 | P27695 | 1/20 | 0.36 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.36 |
| ▸ | THPO | P40225 | 1/20 | 0.36 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.36 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.36 |
| ▸ | PDK2 | Q15119 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24019838 | 0.81 | ALOX15 (0.41) | ALOX15MAPTCYP1A2 | |
| SCHEMBL18236168 | 0.81 | MAPT (0.36) | ALOX15MAPTKDM4ENPC1RAB9A | |
| SCHEMBL25768609 | 0.80 | ALOX15 (0.40) | ALOX15LMNANUDT1 | |
| SCHEMBL18415311 | 0.78 | NTRK1 (0.38) | MAPTKDM4ENPC1RAB9AALDH1A1 | |
| SCHEMBL23849220 | 0.77 | MAPK1 (0.38) | ALOX15MAPTKDM4EALDH1A1LMNA | |
| SCHEMBL5651735 | 0.75 | — | — | |
| SCHEMBL24112533 | 0.73 | ALDH1A1 (0.45) | ALOX15MAPTKDM4ENPC1ALDH1A1 | |
| SCHEMBL1440454 | 0.70 | PTPN11 (0.38) | MAPTKDM4ENPC1RAB9AALDH1A1 | |
| SCHEMBL30881439 | 0.70 | BAZ2B (0.33) | MAPTKDM4ENPC1RAB9AALDH1A1 | |
| SCHEMBL1507062 | 0.67 | MAOB (0.57) | NPC1RAB9ATP53TSHRPTK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2021252644-A1 | INHIBITORS OF CYSTEINE PROTEASES AND METHODS OF USE THEREOF | Pardes Biosciences, Inc. (US) | 2021-12-16 | — | — | WO | disclosed |