Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.45 |
| ▸ | ATF4 | P18848 | 9/20 | 0.45 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.44 |
| ▸ | LMNA | P02545 | 2/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | GRIN1 | Q05586 | 1/20 | 0.40 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.40 |
| ▸ | GBA1 | P04062 | 1/20 | 0.40 |
| ▸ | TP53 | P04637 | 2/20 | 0.39 |
| ▸ | THRB | P10828 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24116821 | 0.87 | ATF4 (0.44) | ALDH1A1ATF4TDP1LMNAGRIN1 | |
| SCHEMBL21116595 | 0.85 | ATF4 (0.45) | ALDH1A1ATF4TDP1LMNATP53 | |
| SCHEMBL24323067 | 0.84 | ATF4 (0.44) | ALDH1A1ATF4 | |
| SCHEMBL24116849 | 0.84 | ATF4 (0.42) | ALDH1A1ATF4LMNAGRIN1GRIN2B | |
| SCHEMBL24116692 | 0.84 | HDAC3 (0.41) | ALDH1A1ATF4 | |
| SCHEMBL24116822 | 0.83 | SMN1; SMN2 (0.54) | ALDH1A1TP53 | |
| SCHEMBL24116739 | 0.81 | HDAC3 (0.47) | ALDH1A1ATF4 | |
| SCHEMBL24116706 | 0.81 | POLB (0.50) | ALDH1A1ATF4LMNAGAATP53 | |
| SCHEMBL22669296 | 0.79 | ATF4 (0.55) | ALDH1A1ATF4GRIN1GRIN2BGBA1 | |
| SCHEMBL21117009 | 0.78 | ATF4 (0.54) | ATF4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20210393599-A1 | MODULATORS OF THE INTEGRATED STRESS PATHWAY | ABBVIE INC. | 2021-12-23 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20210393599-A1 | MODULATORS OF THE INTEGRATED STRESS PATHWAY | ATF4, ATF1, DDIT3 | ALDH1A1 3433/4885ATF4 1/4885TDP1 2489/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.