Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ATF4 | P18848 | 9/20 | 0.55 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.51 |
| ▸ | GRIN1 | Q05586 | 2/20 | 0.48 |
| ▸ | GRIN2B | Q13224 | 2/20 | 0.48 |
| ▸ | GBA1 | P04062 | 1/20 | 0.45 |
| ▸ | MEN1 | O00255 | 2/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.45 |
| ▸ | PPARG | P37231 | 1/20 | 0.45 |
| ▸ | HTT | P42858 | 1/20 | 0.45 |
| ▸ | NCOA2 | Q15596 | 1/20 | 0.45 |
| ▸ | NCOA1 | Q15788 | 1/20 | 0.45 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.45 |
| ▸ | NR2E3 | Q9Y5X4 | 1/20 | 0.45 |
| ▸ | NCOR2 | Q9Y618 | 1/20 | 0.45 |
| ▸ | NCOA3 | Q9Y6Q9 | 1/20 | 0.45 |
| ▸ | MAPT | P10636 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19555345 | 0.86 | ALDH1A1 (0.55) | ATF4ALDH1A1GRIN1GRIN2BMEN1 | |
| SCHEMBL22669060 | 0.86 | ATF4 (0.52) | ATF4ALDH1A1GRIN1GRIN2BMEN1 | |
| SCHEMBL22669308 | 0.85 | ATF4 (0.48) | ATF4ALDH1A1GRIN1GRIN2BMEN1 | |
| SCHEMBL24116706 | 0.83 | POLB (0.50) | ATF4ALDH1A1MEN1KMT2AHTT | |
| SCHEMBL22669402 | 0.82 | ATF4 (0.46) | ATF4ALDH1A1GRIN1GRIN2BMEN1 | |
| SCHEMBL25796695 | 0.82 | ALDH1A1 (0.59) | ATF4ALDH1A1GRIN1GRIN2BMEN1 | |
| SCHEMBL25796705 | 0.82 | ALDH1A1 (0.50) | ATF4ALDH1A1GRIN1GRIN2BMEN1 | |
| SCHEMBL20999199 | 0.81 | ALDH1A1 (0.52) | ATF4ALDH1A1GRIN1GRIN2BMEN1 | |
| SCHEMBL25802434 | 0.81 | ALDH1A1 (0.51) | ATF4ALDH1A1GRIN1GRIN2BMEN1 | |
| SCHEMBL24116821 | 0.80 | ATF4 (0.44) | ATF4ALDH1A1GRIN1GRIN2BMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20200361941-A1 | MODULATORS OF THE INTEGRATED STRESS PATHWAY | ABBVIE INC. | 2020-11-19 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20200361941-A1 | MODULATORS OF THE INTEGRATED STRESS PATHWAY | ATF4, ATF1, DDIT3 | ATF4 1/4885ALDH1A1 3433/4885GRIN1 1690/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.