Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAB9A | P51151 | 3/20 | 0.56 |
| ▸ | EPHX1 | P07099 | 4/20 | 0.51 |
| ▸ | EPHX2 | P34913 | 3/20 | 0.49 |
| ▸ | CASR | P41180 | 1/20 | 0.49 |
| ▸ | MEN1 | O00255 | 5/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.48 |
| ▸ | MAPT | P10636 | 2/20 | 0.48 |
| ▸ | LMNA | P02545 | 2/20 | 0.48 |
| ▸ | HTT | P42858 | 2/20 | 0.48 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.48 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.48 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.48 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.48 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.48 |
| ▸ | NPC1 | O15118 | 1/20 | 0.48 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.47 |
| ▸ | MAOA | P21397 | 1/20 | 0.47 |
| ▸ | MAOB | P27338 | 1/20 | 0.47 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24118279 | 0.88 | MEN1 (0.59) | RAB9AMEN1KMT2AMAPTLMNA | |
| SCHEMBL24118254 | 0.88 | FPR2 (0.48) | RAB9AMEN1KMT2AMAPTLMNA | |
| SCHEMBL24118405 | 0.87 | KMT2A (0.44) | RAB9AMEN1KMT2ALMNANPC1 | |
| SCHEMBL23593230 | 0.83 | CYP1A2 (0.50) | RAB9ACYP1A2CYP3A4CYP2D6CYP2C19 | |
| SCHEMBL24117952 | 0.82 | KMT2A (0.58) | RAB9AMEN1KMT2AMAPTLMNA | |
| SCHEMBL24118338 | 0.80 | GCGR (0.46) | EPHX2ALDH1A1CNR1 | |
| SCHEMBL24118326 | 0.79 | GCG (0.49) | RAB9AKMT2ALMNANPC1ALDH1A1 | |
| SCHEMBL24118062 | 0.78 | IDO1 (0.54) | MEN1KMT2AALDH1A1TP53SMN1; SMN2 | |
| SCHEMBL24118042 | 0.78 | IDO1 (0.53) | RAB9AMEN1KMT2AMAPTLMNA | |
| SCHEMBL11007034 | 0.76 | MEN1 (0.79) | RAB9AMEN1KMT2AMAPTLMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20210393600-A1 | Novel [1.1.1] Bicyclo Compounds as Indoleamine 2,3-Dioxygenase Inhibitors | MERCK SHARP & DOHME CORP. (US) | 2021-12-23 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20210393600-A1 | Novel [1.1.1] Bicyclo Compounds as Indoleamine 2,3-Dioxygenase Inhibitors | IDO1, IDO2, TPH1 | RAB9A 2866/4885EPHX1 670/4885EPHX2 805/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.