Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 9/20 | 0.42 |
| ▸ | RAB9A | P51151 | 9/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.42 |
| ▸ | MAPT | P10636 | 3/20 | 0.42 |
| ▸ | NFKB1 | P19838 | 2/20 | 0.42 |
| ▸ | NFKB2 | Q00653 | 2/20 | 0.42 |
| ▸ | RELA | Q04206 | 2/20 | 0.42 |
| ▸ | TP53 | P04637 | 1/20 | 0.42 |
| ▸ | GAA | P10253 | 1/20 | 0.42 |
| ▸ | HTT | P42858 | 1/20 | 0.42 |
| ▸ | MAPK14 | Q16539 | 2/20 | 0.41 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.40 |
| ▸ | MEN1 | O00255 | 3/20 | 0.40 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.40 |
| ▸ | SIRT1 | Q96EB6 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.39 |
| ▸ | PPARG | P37231 | 1/20 | 0.39 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8460319 | 0.83 | MEN1 (0.52) | NPC1RAB9ASMN1; SMN2MAPTNFKB1 | |
| SCHEMBL24125170 | 0.82 | NPC1 (0.36) | NPC1RAB9ASMN1; SMN2MAPTNFKB1 | |
| SCHEMBL25921185 | 0.81 | MAPT (0.46) | NPC1RAB9ASMN1; SMN2MAPTNFKB1 | |
| SCHEMBL24124316 | 0.80 | GPR27 (0.59) | NPC1RAB9ASMN1; SMN2MAPTTP53 | |
| SCHEMBL24124786 | 0.79 | KMT2A (0.46) | NPC1RAB9ASMN1; SMN2MAPTNFKB1 | |
| SCHEMBL9147195 | 0.79 | MEN1 (0.51) | NPC1RAB9ASMN1; SMN2MAPTNFKB1 | |
| SCHEMBL24125078 | 0.79 | MAPT (0.43) | NPC1RAB9ASMN1; SMN2MAPTNFKB1 | |
| SCHEMBL24124857 | 0.77 | AVPR2 (0.42) | NPC1RAB9ASMN1; SMN2MAPTTP53 | |
| SCHEMBL24124937 | 0.77 | NPC1 (0.41) | NPC1RAB9ASMN1; SMN2MAPTTP53 | |
| SCHEMBL24124243 | 0.77 | NPC1 (0.50) | NPC1RAB9ASMN1; SMN2MAPTNFKB1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2021257544-A1 | SOX11 INHIBITORS FOR TREATING MANTLE CELL LYMPHOMA | ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI (US) | 2021-12-23 | — | — | WO | disclosed |