Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTT | P42858 | 6/20 | 0.60 |
| ▸ | NPC1 | O15118 | 2/20 | 0.59 |
| ▸ | RAB9A | P51151 | 1/20 | 0.59 |
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.58 |
| ▸ | LMNA | P02545 | 4/20 | 0.58 |
| ▸ | MAPT | P10636 | 9/20 | 0.57 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.57 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.57 |
| ▸ | MEN1 | O00255 | 3/20 | 0.57 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.57 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.57 |
| ▸ | HPGD | P15428 | 1/20 | 0.57 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.55 |
| ▸ | POLB | P06746 | 1/20 | 0.55 |
| ▸ | NOD2 | Q9HC29 | 1/20 | 0.52 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.51 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.51 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.51 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.50 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24124917 | 0.80 | POLB (0.60) | HTTNPC1RAB9AALDH1A1LMNA | |
| SCHEMBL24125017 | 0.80 | MAPT (0.55) | HTTNPC1RAB9AALDH1A1LMNA | |
| SCHEMBL24124322 | 0.80 | KMT2A (0.75) | HTTNPC1RAB9AALDH1A1LMNA | |
| SCHEMBL24124787 | 0.80 | NPC1 (0.51) | HTTNPC1RAB9AALDH1A1LMNA | |
| SCHEMBL25927886 | 0.79 | MAPT (0.58) | HTTALDH1A1LMNAMAPTSMN1; SMN2 | |
| SCHEMBL24125182 | 0.77 | ALDH1A1 (0.55) | HTTNPC1RAB9AALDH1A1LMNA | |
| SCHEMBL19630003 | 0.77 | HTT (0.59) | HTTNPC1RAB9AALDH1A1LMNA | |
| SCHEMBL24125210 | 0.76 | HDAC1 (0.68) | NPC1RAB9AALDH1A1LMNAMAPT | |
| SCHEMBL23781330 | 0.76 | HTT (0.77) | HTTNPC1RAB9AALDH1A1LMNA | |
| SCHEMBL619633 | 0.76 | HTT (1.00) | HTTNPC1RAB9AALDH1A1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2021257544-A1 | SOX11 INHIBITORS FOR TREATING MANTLE CELL LYMPHOMA | ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI (US) | 2021-12-23 | — | — | WO | disclosed |