Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BCHE | P06276 | 1/20 | 0.35 |
| ▸ | GLI1 | P08151 | 1/20 | 0.33 |
| ▸ | DPP4 | P27487 | 1/20 | 0.31 |
| ▸ | MEN1 | O00255 | 1/20 | 0.30 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.30 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23771116 | 0.79 | MEN1 (0.33) | MEN1KMT2ASMN1; SMN2 | |
| SCHEMBL23592552 | 0.75 | SMN1; SMN2 (0.33) | BCHESMN1; SMN2 | |
| SCHEMBL8596836 | 0.69 | — | — | |
| SCHEMBL15432000 | 0.68 | PDK1 (0.33) | BCHE | |
| SCHEMBL26938037 | 0.67 | HRH3 (0.33) | MEN1KMT2ASMN1; SMN2 | |
| SCHEMBL2537519 | 0.67 | BCHE (0.42) | BCHEDPP4MEN1KMT2ASMN1; SMN2 | |
| SCHEMBL20095980 | 0.67 | BCHE (0.36) | BCHEGLI1DPP4MEN1KMT2A | |
| SCHEMBL20095979 | 0.67 | BCHE (0.36) | BCHEGLI1DPP4MEN1KMT2A | |
| SCHEMBL129723 | 0.65 | ALDH1A1 (0.44) | MEN1KMT2ASMN1; SMN2 | |
| SCHEMBL23324955 | 0.65 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2024081363-A1 | COMPOSITION COMPRISING A FIRST RAS INHIBITOR, SECOND RAS INHIBITOR AND A SHP2 INHIBITOR FOR USE IN THE TREATMENT OF CANCER | Revolution Medicines, Inc. (US) | 2024-04-18 | — | — | WO | disclosed |
| WO-2021257736-A1 | METHODS FOR DELAYING, PREVENTING, AND TREATING ACQUIRED RESISTANCE TO RAS INHIBITORS | Revolution Medicines, Inc. (US) | 2021-12-23 | — | — | WO | disclosed |