Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | METAP2 | P50579 | 1/20 | 0.54 |
| ▸ | F2 | P00734 | 1/20 | 0.53 |
| ▸ | KDR | P35968 | 2/20 | 0.52 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.52 |
| ▸ | FYN | P06241 | 1/20 | 0.51 |
| ▸ | LTA4H | P09960 | 1/20 | 0.48 |
| ▸ | BRAF | P15056 | 1/20 | 0.45 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.44 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.44 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.43 |
| ▸ | GABRG2 | P18507 | 1/20 | 0.43 |
| ▸ | GABRB3 | P28472 | 1/20 | 0.43 |
| ▸ | GABRA5 | P31644 | 1/20 | 0.43 |
| ▸ | GABRA3 | P34903 | 1/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
| ▸ | NPC1 | O15118 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
| ▸ | HPGD | P15428 | 1/20 | 0.43 |
| ▸ | HTT | P42858 | 1/20 | 0.43 |
| ▸ | RAB9A | P51151 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13743125 | 0.87 | KCNH2 (0.56) | METAP2KDRKCNH2FYNLTA4H | |
| SCHEMBL4191787 | 0.83 | FYN (0.71) | METAP2KDRKCNH2FYNBRAF | |
| SCHEMBL24137549 | 0.83 | FYN (0.61) | METAP2KDRKCNH2FYNBRAF | |
| SCHEMBL24137924 | 0.81 | BRAF (0.52) | METAP2KDRKCNH2FYNBRAF | |
| SCHEMBL15463279 | 0.80 | METAP2 (0.62) | METAP2FFAR1HTT | |
| SCHEMBL4932096 | 0.80 | KCNH2 (0.53) | METAP2F2KDRKCNH2FYN | |
| SCHEMBL4650070 | 0.78 | HTR7 (0.58) | F2KDRKCNH2FYNBRAF | |
| SCHEMBL4146617 | 0.78 | FYN (0.64) | METAP2KDRKCNH2FYNCYP11B2 | |
| SCHEMBL28563905 | 0.77 | KCNH2 (0.51) | METAP2KDRKCNH2FYNLTA4H | |
| SCHEMBL24137805 | 0.76 | HTR7 (0.60) | KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2021263129-A1 | KINASE INHIBITOR COMPOUNDS AND COMPOSITIONS AND METHODS OF USE | ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI (US) | 2021-12-30 | — | — | WO | disclosed |