Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AHR | P35869 | 1/20 | 0.66 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.47 |
| ▸ | MAPT | P10636 | 4/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.47 |
| ▸ | RAB9A | P51151 | 3/20 | 0.47 |
| ▸ | HPGD | P15428 | 2/20 | 0.47 |
| ▸ | GAA | P10253 | 2/20 | 0.47 |
| ▸ | GLA | P06280 | 1/20 | 0.47 |
| ▸ | PPARG | P37231 | 1/20 | 0.47 |
| ▸ | NCOA2 | Q15596 | 1/20 | 0.47 |
| ▸ | NCOA1 | Q15788 | 1/20 | 0.47 |
| ▸ | ILK | Q13418 | 3/20 | 0.46 |
| ▸ | F2RL3 | Q96RI0 | 1/20 | 0.45 |
| ▸ | MEN1 | O00255 | 3/20 | 0.44 |
| ▸ | NPC1 | O15118 | 3/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.44 |
| ▸ | TP53 | P04637 | 2/20 | 0.44 |
| ▸ | HCRTR1 | O43613 | 1/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25877004 | 0.89 | AHR (0.70) | AHRALDH1A1MAPTSMN1; SMN2KDM4E | |
| SCHEMBL24140755 | 0.87 | AHR (0.67) | AHRALDH1A1MAPTSMN1; SMN2KDM4E | |
| SCHEMBL4802899 | 0.82 | AHR (0.76) | AHRALDH1A1MAPTSMN1; SMN2KDM4E | |
| SCHEMBL25876975 | 0.82 | AHR (0.67) | AHRALDH1A1MAPTSMN1; SMN2KDM4E | |
| SCHEMBL4803129 | 0.81 | AHR (0.79) | AHRALDH1A1MAPTSMN1; SMN2KDM4E | |
| SCHEMBL30307425 | 0.80 | AHR (1.00) | AHRALDH1A1MAPTSMN1; SMN2KDM4E | |
| SCHEMBL4797786 | 0.80 | AHR (1.00) | AHRALDH1A1MAPTSMN1; SMN2KDM4E | |
| SCHEMBL30288215 | 0.80 | AHR (1.00) | AHRALDH1A1MAPTSMN1; SMN2KDM4E | |
| SCHEMBL4803017 | 0.79 | AHR (0.79) | AHRALDH1A1MAPTSMN1; SMN2KDM4E | |
| SCHEMBL11188660 | 0.77 | AHR (0.56) | AHRALDH1A1MAPTSMN1; SMN2KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2021263079-A1 | TREX1 INHIBITORS AND USES THEREOF | TEMPEST THERAPEUTICS, INC. (US) | 2021-12-30 | — | — | WO | disclosed |