Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 4/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.48 |
| ▸ | TP53 | P04637 | 3/20 | 0.48 |
| ▸ | ADRA2A | P08913 | 7/20 | 0.38 |
| ▸ | ADRA2B | P18089 | 3/20 | 0.38 |
| ▸ | ADRA2C | P18825 | 3/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | RAD51 | Q06609 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.34 |
| ▸ | NPC1 | O15118 | 2/20 | 0.34 |
| ▸ | RAB9A | P51151 | 2/20 | 0.34 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.34 |
| ▸ | CYP1A2 | P05177 | 3/20 | 0.33 |
| ▸ | CYP1A1 | P04798 | 2/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.32 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.32 |
| ▸ | HPGD | P15428 | 1/20 | 0.32 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.32 |
| ▸ | EGLN2 | Q96KS0 | 1/20 | 0.31 |
| ▸ | MEN1 | O00255 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22154712 | 0.78 | MAPT (0.53) | MAPTKDM4ETP53ALDH1A1NPC1 | |
| SCHEMBL7012895 | 0.76 | LMNA (0.56) | MAPTTP53ADRA2AADRA2BADRA2C | |
| SCHEMBL11544937 | 0.76 | LMNA (0.56) | MAPTTP53ADRA2AADRA2BADRA2C | |
| SCHEMBL21372065 | 0.76 | MAPT (0.65) | MAPTKDM4ETP53LMNAALDH1A1 | |
| SCHEMBL14516252 | 0.74 | ADRB2 (0.47) | MAPTKDM4EADRA2AADRA2BADRA2C | |
| SCHEMBL19543315 | 0.74 | MAPT (0.50) | MAPTKDM4ETP53ALDH1A1NPC1 | |
| SCHEMBL15383744 | 0.74 | TP53 (0.53) | MAPTKDM4ETP53LMNAALDH1A1 | |
| SCHEMBL20783238 | 0.74 | TP53 (0.48) | MAPTKDM4ETP53NPC1RAB9A | |
| SCHEMBL526383 | 0.73 | MAPT (0.58) | MAPTKDM4ETP53ADRA2AADRA2B | |
| SCHEMBL24303801 | 0.73 | LMNA (0.50) | MAPTKDM4ELMNARAD51ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2021262910-A2 | TUBULYSINS AND PROTEIN-TUBULYSIN CONJUGATES | REGENERON PHARMACEUTICALS, INC. (US) | 2021-12-30 | — | — | WO | disclosed |