Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DGAT1 | O75907 | 2/20 | 0.49 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.49 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.48 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.46 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.46 |
| ▸ | PAK4 | O96013 | 1/20 | 0.46 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.46 |
| ▸ | LTK | P29376 | 1/20 | 0.46 |
| ▸ | MAP2K2 | P36507 | 1/20 | 0.46 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.46 |
| ▸ | CDK8 | P49336 | 1/20 | 0.46 |
| ▸ | RPS6KA3 | P51812 | 1/20 | 0.46 |
| ▸ | PRKX | P51817 | 1/20 | 0.46 |
| ▸ | NEK2 | P51955 | 1/20 | 0.46 |
| ▸ | LIMK1 | P53667 | 1/20 | 0.46 |
| ▸ | CDK5 | Q00535 | 1/20 | 0.46 |
| ▸ | PRKCQ | Q04759 | 1/20 | 0.46 |
| ▸ | MAP4K2 | Q12851 | 1/20 | 0.46 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.46 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31027884 | 0.86 | HDAC6 (0.64) | DGAT1KCNH2HDAC6CHEK1PRKD3 | |
| SCHEMBL21705377 | 0.86 | HDAC6 (0.64) | DGAT1KCNH2HDAC6CHEK1PRKD3 | |
| SCHEMBL24141149 | 0.82 | HDAC6 (0.71) | HDAC6SCDKDM4ENPC1ALDH1A1 | |
| SCHEMBL5579984 | 0.81 | CHEK1 (0.59) | DGAT1KCNH2CHEK1PRKD3PAK4 | |
| SCHEMBL10579325 | 0.81 | DGAT1 (0.51) | DGAT1KCNH2HDAC6CHEK1PRKD3 | |
| SCHEMBL24141162 | 0.81 | DGAT1 (0.48) | DGAT1KCNH2HDAC6CHEK1PRKD3 | |
| SCHEMBL26816963 | 0.76 | HDAC6 (0.57) | DGAT1KCNH2HDAC6SCDNPBWR1 | |
| SCHEMBL2324234 | 0.75 | NPC1 (0.62) | HDAC6CHEK1PRKD3PAK4PDGFRA | |
| SCHEMBL10577324 | 0.75 | DGAT1 (0.46) | DGAT1KCNH2HDAC6CHEK1PRKD3 | |
| SCHEMBL415254 | 0.75 | CHEK1 (0.55) | DGAT1KCNH2CHEK1PRKD3PAK4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2024105635-A1 | USES OF ZLN-005 AND RELATED COMPOUNDS | KYOTO PREFECTURAL UNIVERSITY OF MEDICINE (JP) | 2024-05-23 | — | — | WO | disclosed |
| WO-2023244685-A1 | TREATMENT OF AGING-RELATED CHANGES AND DISEASES | TRANQUIS THERAPEUTICS, INC. (US) | 2023-12-21 | — | — | WO | disclosed |
| WO-2023205401-A1 | TREATMENT OF DISEASES ASSOCIATED WITH REDUCTIVE STRESS | Rdiscovery, LLC (US) | 2023-10-26 | — | — | WO | disclosed |
| WO-2023081656-A1 | SELECTION AND TREATMENT OF SUBJECTS HAVING A CIRCULATING MYELOID CELL INFLAMMATORY PHENOTYPE | TRANQUIS THERAPEUTICS, INC. (US) | 2023-05-11 | — | — | WO | disclosed |
| WO-2021262617-A1 | TREATMENT OF SYSTEMIC IMMUNE ACTIVATION SYNDROMES | TRANQUIS THERAPEUTICS, INC. (US) | 2021-12-30 | — | — | WO | disclosed |