Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DGAT1 | O75907 | 1/20 | 0.46 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.46 |
| ▸ | GUSB | P08236 | 1/20 | 0.43 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.41 |
| ▸ | SCD | O00767 | 1/20 | 0.41 |
| ▸ | NPBWR1 | P48145 | 3/20 | 0.40 |
| ▸ | TP53 | P04637 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.38 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.38 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.38 |
| ▸ | PAK4 | O96013 | 1/20 | 0.38 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.38 |
| ▸ | LTK | P29376 | 1/20 | 0.38 |
| ▸ | MAP2K2 | P36507 | 1/20 | 0.38 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.38 |
| ▸ | CDK8 | P49336 | 1/20 | 0.38 |
| ▸ | RPS6KA3 | P51812 | 1/20 | 0.38 |
| ▸ | PRKX | P51817 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10577338 | 0.91 | DGAT1 (0.57) | DGAT1KCNH2HDAC6SCDNPBWR1 | |
| SCHEMBL10580688 | 0.91 | HDAC6 (0.52) | DGAT1KCNH2HDAC6SCDNPBWR1 | |
| SCHEMBL10574665 | 0.90 | NPBWR1 (0.47) | HDAC6NPBWR1TP53MAPTSMN1; SMN2 | |
| SCHEMBL10576840 | 0.89 | HDAC6 (0.36) | DGAT1KCNH2HDAC6NPBWR1TP53 | |
| SCHEMBL10577985 | 0.89 | NPBWR1 (0.46) | DGAT1KCNH2HDAC6NPBWR1TRPV1 | |
| SCHEMBL10578691 | 0.89 | GUSB (0.43) | GUSBHDAC6NPBWR1TP53MAPT | |
| SCHEMBL10578441 | 0.89 | HDAC6 (0.46) | DGAT1KCNH2HDAC6SCDNPBWR1 | |
| SCHEMBL10574691 | 0.88 | KDM4E (0.43) | GUSBHDAC6SCDMAPTSMN1; SMN2 | |
| SCHEMBL10574912 | 0.87 | MITF (0.37) | DGAT1KCNH2HDAC6NPBWR1TP53 | |
| SCHEMBL10574269 | 0.87 | NPC1 (0.48) | GUSBHDAC6NPBWR1TP53MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4882342-A | CARDIOVASCULAR DISORDERS | BOEHRINGER MANNHEIM GMBH (DE) | 1989-11-21 | — | — | US | disclosed |
| EP-0266558-A2 | 5-Alkylbenzimidazoles, process for their preparation and medicaments containing them | Roche Diagnostics GmbH (DE) | 1988-05-11 | — | — | EP | disclosed |