Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR1D1 | P20393 | 8/20 | 0.50 |
| ▸ | METAP2 | P50579 | 3/20 | 0.40 |
| ▸ | HTR2A | P28223 | 1/20 | 0.38 |
| ▸ | CHEK1 | O14757 | 3/20 | 0.38 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.37 |
| ▸ | TBXAS1 | P24557 | 1/20 | 0.37 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.36 |
| ▸ | CDK1 | P06493 | 1/20 | 0.36 |
| ▸ | PRKACA | P17612 | 1/20 | 0.36 |
| ▸ | CDK2 | P24941 | 1/20 | 0.36 |
| ▸ | CSNK1D | P48730 | 1/20 | 0.36 |
| ▸ | GSK3A | P49840 | 1/20 | 0.36 |
| ▸ | CDK5 | Q00535 | 1/20 | 0.36 |
| ▸ | PRKCD | Q05655 | 1/20 | 0.36 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.36 |
| ▸ | CDC42BPA | Q5VT25 | 1/20 | 0.36 |
| ▸ | MARK2 | Q7KZI7 | 1/20 | 0.36 |
| ▸ | AAK1 | Q2M2I8 | 1/20 | 0.36 |
| ▸ | HTR6 | P50406 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24144465 | 0.90 | NR1D1 (0.48) | NR1D1METAP2HTR2ACHEK1AAK1 | |
| SCHEMBL24142979 | 0.86 | NR1D1 (0.67) | NR1D1 | |
| SCHEMBL24143664 | 0.84 | NR1D1 (0.44) | NR1D1METAP2HTR2ACHEK1TBXAS1 | |
| SCHEMBL24143870 | 0.84 | NR1D1 (0.46) | NR1D1METAP2HTR2ACHEK1AAK1 | |
| SCHEMBL24143542 | 0.84 | NR1D1 (0.53) | NR1D1HTR2AAAK1 | |
| SCHEMBL24143036 | 0.84 | HTR2A (0.54) | NR1D1METAP2HTR2ACHEK1AAK1 | |
| SCHEMBL24143866 | 0.83 | NR1D1 (0.50) | NR1D1METAP2CHEK1AAK1 | |
| SCHEMBL24144078 | 0.83 | NR1D1 (0.48) | NR1D1METAP2CHEK1 | |
| SCHEMBL24144070 | 0.83 | HTR6 (0.54) | NR1D1CYP19A1HTR6 | |
| SCHEMBL24143742 | 0.81 | NR1D1 (0.47) | NR1D1METAP2HTR2ACHEK1AAK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2021263278-A1 | REV-ERB AGONISTS FOR THE TREATMENT OF TH17-MEDIATED INFLAMMATORY DISORDERS | THE SCRIPPS RESEARCH INSTITUTE (US) | 2021-12-30 | — | — | WO | disclosed |