Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR1D1 | P20393 | 6/20 | 0.71 |
| ▸ | NR4A2 | P43354 | 1/20 | 0.40 |
| ▸ | ICMT | O60725 | 9/20 | 0.39 |
| ▸ | SCN9A | Q15858 | 2/20 | 0.39 |
| ▸ | AAK1 | Q2M2I8 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24144535 | 0.87 | NR1D1 (0.66) | NR1D1ICMTSCN9AAAK1 | |
| SCHEMBL24143591 | 0.86 | NR1D1 (0.64) | NR1D1NR4A2ICMTSCN9AAAK1 | |
| SCHEMBL24143029 | 0.83 | NR1D1 (1.00) | NR1D1 | |
| SCHEMBL24143038 | 0.82 | NR1D1 (0.72) | NR1D1 | |
| SCHEMBL26673713 | 0.81 | NR1D1 (0.61) | NR1D1NR4A2ICMTSCN9AAAK1 | |
| SCHEMBL24144137 | 0.79 | NR1D1 (0.46) | NR1D1 | |
| SCHEMBL24144480 | 0.73 | NR1D1 (0.62) | NR1D1NR4A2ICMT | |
| SCHEMBL24144274 | 0.72 | NR1D1 (0.74) | NR1D1 | |
| SCHEMBL24143545 | 0.71 | NR1D1 (0.55) | NR1D1ICMTAAK1 | |
| SCHEMBL24144007 | 0.69 | NR1D1 (0.64) | NR1D1ICMT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2021263278-A1 | REV-ERB AGONISTS FOR THE TREATMENT OF TH17-MEDIATED INFLAMMATORY DISORDERS | THE SCRIPPS RESEARCH INSTITUTE (US) | 2021-12-30 | — | — | WO | disclosed |