Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BRPF1 | P55201 | 9/20 | 0.40 |
| ▸ | JAK2 | O60674 | 3/20 | 0.39 |
| ▸ | BTK | Q06187 | 3/20 | 0.39 |
| ▸ | BRD4 | O60885 | 3/20 | 0.37 |
| ▸ | BRD9 | Q9H8M2 | 3/20 | 0.37 |
| ▸ | CA12 | O43570 | 1/20 | 0.37 |
| ▸ | CA9 | Q16790 | 1/20 | 0.37 |
| ▸ | KAT2B | Q92831 | 1/20 | 0.37 |
| ▸ | ALOX5 | P09917 | 5/20 | 0.32 |
| ▸ | BRD1 | O95696 | 3/20 | 0.32 |
| ▸ | BRPF3 | Q9ULD4 | 2/20 | 0.32 |
| ▸ | LPL | P06858 | 2/20 | 0.32 |
| ▸ | LIPG | Q9Y5X9 | 2/20 | 0.32 |
| ▸ | IRAK4 | Q9NWZ3 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21645492 | 0.82 | BRPF1 (0.45) | BRPF1BRD4BRD9CA12CA9 | |
| SCHEMBL22290891 | 0.80 | BRPF1 (0.45) | BRPF1BRD4BRD9CA12CA9 | |
| SCHEMBL16364676 | 0.79 | JAK2 (0.37) | JAK2BTKLPLLIPGIRAK4 | |
| SCHEMBL4562321 | 0.76 | BRPF1 (0.50) | BRPF1BRD4BRD9CA12CA9 | |
| SCHEMBL31149544 | 0.76 | BRPF1 (0.50) | BRPF1BRD4BRD9CA12CA9 | |
| SCHEMBL17419151 | 0.74 | JAK2 (0.36) | JAK2BTK | |
| SCHEMBL18239701 | 0.73 | JAK2 (0.37) | JAK2BTKLPLLIPG | |
| SCHEMBL21871447 | 0.72 | IRAK4 (0.38) | JAK2BTKIRAK4 | |
| SCHEMBL1646761 | 0.72 | LPL (0.44) | JAK2BTKCA9LPLLIPG | |
| SCHEMBL15191712 | 0.71 | LPL (0.49) | JAK2BTKCA9LPLLIPG |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20210403479-A1 | INHIBITORS OF HISTONE DEACETYLASE USEFUL FOR THE TREATMENT OR PREVENTION OF HIV INFECTION | MERCK SHARP & DOHME CORP. (US) | 2021-12-30 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20210403479-A1 | INHIBITORS OF HISTONE DEACETYLASE USEFUL FOR THE TREATMENT OR PREVENTION OF HIV INFECTION | HDAC1, HDAC11, HDAC3 | BRPF1 1405/4885JAK2 2797/4885BTK 2233/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.