Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PRMT5 | O14744 | 13/20 | 0.76 |
| ▸ | WDR77 | Q9BQA1 | 12/20 | 0.76 |
| ▸ | ADORA1 | P30542 | 3/20 | 0.54 |
| ▸ | ADORA3 | P0DMS8 | 2/20 | 0.52 |
| ▸ | AHCY | P23526 | 2/20 | 0.52 |
| ▸ | DPP4 | P27487 | 1/20 | 0.52 |
| ▸ | MEN1 | O00255 | 1/20 | 0.52 |
| ▸ | SLC28A1 | O00337 | 1/20 | 0.52 |
| ▸ | MAP3K7 | O43318 | 1/20 | 0.52 |
| ▸ | SLC28A2 | O43868 | 1/20 | 0.52 |
| ▸ | GAPDH | P04406 | 1/20 | 0.52 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.52 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.52 |
| ▸ | ADORA2B | P29275 | 1/20 | 0.52 |
| ▸ | STAT6 | P42226 | 1/20 | 0.52 |
| ▸ | PI4KA | P42356 | 1/20 | 0.52 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.52 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.52 |
| ▸ | PI4K2B | Q8TCG2 | 1/20 | 0.52 |
| ▸ | DOT1L | Q8TEK3 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24146493 | 1.00 | PRMT5 (0.76) | PRMT5WDR77ADORA1ADORA3AHCY | |
| SCHEMBL30128300 | 1.00 | PRMT5 (0.76) | PRMT5WDR77ADORA1ADORA3AHCY | |
| SCHEMBL24146563 | 0.90 | PRMT5 (0.73) | PRMT5WDR77ADORA1 | |
| SCHEMBL24146564 | 0.90 | PRMT5 (0.73) | PRMT5WDR77ADORA1 | |
| SCHEMBL30128302 | 0.90 | PRMT5 (0.73) | PRMT5WDR77ADORA1 | |
| SCHEMBL22501903 | 0.86 | PRMT5 (1.00) | PRMT5WDR77ADORA1AHCY | |
| SCHEMBL22509048 | 0.86 | PRMT5 (0.76) | PRMT5WDR77ADORA1ADORA3AHCY | |
| SCHEMBL22501904 | 0.86 | PRMT5 (1.00) | PRMT5WDR77ADORA1AHCY | |
| SCHEMBL23294215 | 0.86 | PRMT5 (0.76) | PRMT5WDR77ADORA1ADORA3AHCY | |
| SCHEMBL29705817 | 0.86 | PRMT5 (0.76) | PRMT5WDR77ADORA1ADORA3AHCY |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20230174539-A1 | Substituted Pyrrolo[2,3-D]Pyrimidines As Inhibitors Of Protein Arginine Methyl Transferase 5 (PRMT5) | PRELUDE THERAPEUTICS INCORPORATED | 2023-06-08 | — | — | US | disclosed |
| US-20230174539-A1 | Substituted Pyrrolo[2,3-D]Pyrimidines As Inhibitors Of Protein Arginine Methyl Transferase 5 (PRMT5) | PRELUDE THERAPEUTICS INCORPORATED | 2023-06-08 | — | — | US | disclosed |
| US-11524962-B2 | Substituted pyrrolo[2,3-d]pyrimidines as inhibitors of protein arginine methyl transferase 5 (PRMT5) | PRELUDE THERAPEUTICS, INCORPORATED (US) | 2022-12-13 | — | — | US | disclosed |
| US-20210403472-A1 | SELECTIVE INHIBITORS OF PROTEIN ARGININE METHYLTRANSFERASE 5 (PRMT5) | PRELUDE THERAPEUTICS, INCORPORATED | 2021-12-30 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20210403472-A1 | SELECTIVE INHIBITORS OF PROTEIN ARGININE METHYLTRANSFERASE 5 (PRMT5) | PRMT5, PRMT1, PRMT6 | PRMT5 1/4885WDR77 81/4885ADORA1 4422/4885 |
| US-11524962-B2 | Substituted pyrrolo[2,3-d]pyrimidines as inhibitors of protein arginine methyl transferase 5 (PRMT5) | PRMT5, PRMT1, PRMT3 | PRMT5 1/4885WDR77 113/4885ADORA1 3052/4885 |
| US-20230174539-A1 | Substituted Pyrrolo[2,3-D]Pyrimidines As Inhibitors Of Protein Arginine Methyl Transferase 5 (PRMT5) | PRMT5, PRMT1, PRMT3 | PRMT5 1/4885WDR77 112/4885ADORA1 3101/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.