Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CDK8 | P49336 | 2/20 | 0.63 |
| ▸ | ROCK1 | Q13464 | 2/20 | 0.63 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.63 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.63 |
| ▸ | CSF1R | P07333 | 1/20 | 0.63 |
| ▸ | PRKACA | P17612 | 1/20 | 0.63 |
| ▸ | KDR | P35968 | 1/20 | 0.63 |
| ▸ | MAP2K1 | Q02750 | 1/20 | 0.63 |
| ▸ | ACVR1 | Q04771 | 1/20 | 0.63 |
| ▸ | MAP4K2 | Q12851 | 1/20 | 0.63 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.63 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.63 |
| ▸ | DYRK1B | Q9Y463 | 1/20 | 0.63 |
| ▸ | DRD1 | P21728 | 9/20 | 0.48 |
| ▸ | FLT1 | P17948 | 1/20 | 0.47 |
| ▸ | CDK9 | P50750 | 1/20 | 0.47 |
| ▸ | LIMK1 | P53667 | 1/20 | 0.47 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.47 |
| ▸ | MEN1 | O00255 | 1/20 | 0.46 |
| ▸ | NPC1 | O15118 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24155454 | 0.77 | MEN1 (0.43) | CDK8ROCK1CHEK1MAP4K4CSF1R | |
| Hydrochloric Acid SCHEMBL21995536 | 0.76 | MEN1 (0.42) | CDK8ROCK1CHEK1MAP4K4CSF1R | |
| SCHEMBL24155477 | 0.74 | MEN1 (0.44) | CDK8ROCK1CHEK1MAP4K4CSF1R | |
| SCHEMBL22044431 | 0.72 | KDR (0.55) | CDK8ROCK1MAP4K4CSF1RPRKACA | |
| SCHEMBL21995639 | 0.72 | MEN1 (0.52) | DYRK1AMEN1NPC1GAARAB9A | |
| SCHEMBL24155451 | 0.72 | MEN1 (0.49) | KDRMEN1NPC1GAARAB9A | |
| SCHEMBL15698733 | 0.71 | CDK8 (0.66) | CDK8ROCK1CHEK1MAP4K4CSF1R | |
| SCHEMBL24155453 | 0.69 | SCN5A (0.50) | DYRK1AMEN1NPC1GAARAB9A | |
| SCHEMBL15690966 | 0.68 | CDK8 (0.72) | CDK8ROCK1CHEK1MAP4K4CSF1R | |
| SCHEMBL24155635 | 0.68 | MEN1 (0.63) | MEN1NPC1GAARAB9AKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20210403456-A1 | HETEROCYCLIC COMPOUNDS FOR THE TREATMENT OF EPILEPSY | OTSUKA PHARMACEUTICAL CO., LTD. (JP) | 2021-12-30 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20210403456-A1 | HETEROCYCLIC COMPOUNDS FOR THE TREATMENT OF EPILEPSY | SLC6A11, SCN1A, SCN1B | CDK8 933/4885ROCK1 2090/4885CHEK1 4662/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.