4-Hydroxyphenylpyruvic Acid

4-Hydroxyphenylpyruvic Acid

SCHEMBL24157

O=C(O)C(=O)Cc1ccc(O)cc1

nearest known ligand 1.00 ✓ in ChEMBL — recovers established targets

Full drug profile on Sugi Atlas →

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
FNTA P49354 1/20 0.72
FNTB P49356 1/20 0.72
CA2 P00918 2/20 0.67
CAMK2A Q9UQM7 1/20 0.67
F2 P00734 2/20 0.59
CTBP2 P56545 1/20 0.59
PLG P00747 1/20 0.57
PRSS1 P07477 1/20 0.57
PRSS2 P07478 1/20 0.57
C1S P09871 1/20 0.57
PRSS3 P35030 1/20 0.57
CES2 O00748 1/20 0.52
CES1 P23141 1/20 0.52
ALDH1A1 P00352 1/20 0.47
CYP1A2 P05177 1/20 0.47
CYP3A4 P08684 1/20 0.47
CYP2C19 P33261 1/20 0.47
ESR1 P03372 3/20 0.47
ESR2 Q92731 3/20 0.47
NPC1 O15118 2/20 0.47

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
4-Hydroxyphenylpyruvic Acid SCHEMBL29007535 0.98 FNTA (0.76) FNTAFNTBCA2CAMK2AF2
4-Hydroxyphenylpyruvic Acid SCHEMBL11057666 0.90 CA2 (0.61) FNTAFNTBCA2CAMK2AF2
4-Hydroxyphenylpyruvic Acid SCHEMBL6248455 0.88 CA2 (0.59) FNTAFNTBCA2CAMK2AF2
Kurasoin A SCHEMBL30799774 0.84 FNTA (1.00) FNTAFNTBCA2CAMK2ACTBP2
4-Hydroxyphenylpyruvic Acid SCHEMBL14813084 0.84 F2 (0.57) FNTAFNTBCA2CAMK2AF2
4-Hydroxyphenylpyruvic Acid SCHEMBL14813081 0.84 F2 (0.57) FNTAFNTBCA2CAMK2AF2
Tyrosine SCHEMBL14746937 0.82 SLC7A5 (0.77) FNTAFNTBF2SLC7A5
Tyrosine SCHEMBL14746940 0.82 SLC7A5 (0.77) FNTAFNTBF2SLC7A5
4-Hydroxyphenylpyruvic Acid SCHEMBL28660024 0.81 FNTA (0.50) FNTAFNTBCA2CAMK2AF2
4-Hydroxyphenylpyruvic Acid SCHEMBL14717758 0.81 FNTA (0.50) FNTAFNTBCA2CAMK2AF2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Appears in 10594 patents — a generic fragment claimed broadly, so it's down-weighted as IP noise. Top by claim status then date:

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20260144260-A1 COMPOSITION AND METHOD FOR IMPROVING AGRONOMIC TRAITS OF A PLANT THE BOARD OF TRUSTEES OF THE UNIVERSITY OF ILLINOIS (US) 2026-05-28 US claimed
EP-4747627-A1 METHODS AND SYSTEMS FOR PREDICTIVE CLASSIFICATION BY MASS SPECTROMETRY AND TRAINED LARGE SPECTRAL MODELS Matterworks Inc (US) 2026-05-27 EP claimed
EP-3869192-B1 METHOD FOR QUANTITATIVE DETECTION OF VARIOUS METABOLITES IN BIOLOGICAL SAMPLE HUMAN METABOLOMICS INST INC (CN) 2026-05-13 EP claimed
US-20260123658-A1 Methods of Increasing the Beneficial Properties of Fermented Foods The Brd. of Trustees of the Univ. of Illinois (US) 2026-05-07 US claimed
EP-4723888-A2 MIXTURE OF AGRICULTURALLY ACTIVE COMPOUNDS AND SPRAY ADJUVANTS Speedagro Inc. (US) 2026-04-15 EP claimed
EP-3664607-B1 HERBICIDAL COMPOSITIONS COMPRISING 4-AMINO-3-CHLORO-5-FLUORO-6-(4-CHLORO-2-FLUORO-3-METHOXYPHENYL) PYRIDINE-2-CARBOXYLIC ACID OR A DERIVATIVE THEREOF AND TEMBOTRIONE AND/OR TOPRAMEZONE CORTEVA AGRISCIENCE LLC (US) 2026-04-08 EP claimed
US-20260091067-A1 METHODS AND USES OF MICROBIOME COMPOSITIONS, COMPONENTS, OR METABOLITES FOR TREATING INSULIN-ASSOCIATED DISEASES MARVELBIOME INC (US) 2026-04-02 US claimed
EP-4714942-A1 SUBSTITUTED HALOALKYL SULFONANILIDE HERBICIDES FMC Corporation (US) 2026-03-25 EP claimed
EP-3346842-B1 STABLE INOCULANT COMPOSITIONS AND METHODS FOR PRODUCING SAME NOVONESIS PLANT BIOSOLUTIONS AS (DK) 2026-03-25 EP claimed
US-12564190-B2 Biobased herbicide enhancer agent and method for using the same FYTEKO SA (BE) 2026-03-03 US claimed
US-4859591-A Transamination process for producing amino acids W. R. GRACE & CO.-CONN. (US) 1989-08-22 US claimed
US-4824781-A FROM LACTOBACILLUS DEGUSSA AKTIENGESELLSCHAFT (DE) 1989-04-25 US claimed
EP-0120208-B1 MICROBIOLOGICALLY PRODUCED L-PHENYLALANIN-DEHYDROGENASE, PROCESS FOR OBTAINING IT AND ITS USE Degussa Aktiengesellschaft (DE) 1989-03-22 EP claimed
EP-0293514-A1 The cloning and utilization of aminotransferase genes THE NUTRASWEET COMPANY (US) 1988-12-07 EP claimed
EP-0273202-A2 Use of hydroxycarboxylic acids to enhance therapeutic effects of topical compositions for fungal infections and pigmented spots. Van Scott, Eugene J., Dr. (US) 1988-07-06 EP claimed
EP-0188712-A1 Process for obtaining phenyl alanine-containing microorganisms and their use in the preparation of L-alpha-amino acids Degussa Aktiengesellschaft (DE) 1986-07-30 EP claimed
US-4590161-A AEROBIC CULTIVATION OF BREUIBACTERIUM DEGUSSA AKTIENGESELLSCHAFT (DE) 1986-05-20 US claimed
US-4518692-A ALPHA-KETO ACIDS, L-ASPARTIC ACID, TRANSAMINASE GENETICS INSTITUTE, INC. (US) 1985-05-21 US claimed
EP-0116860-A1 The cloning and utilization of aminotransferase genes THE NUTRASWEET COMPANY (US) 1984-08-29 EP claimed
US-4110166-A CULTIVATION, CARBOXYLIC ACID FUJISAWA PHARMACEUTICAL CO., LTD. (JP) 1978-08-29 US claimed