Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DPP4 | P27487 | 5/20 | 0.44 |
| ▸ | DPP7 | Q9UHL4 | 2/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.39 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.39 |
| ▸ | SLC6A2 | P23975 | 2/20 | 0.39 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.39 |
| ▸ | SLC6A3 | Q01959 | 2/20 | 0.39 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.39 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.38 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.38 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.38 |
| ▸ | ARG1 | P05089 | 1/20 | 0.35 |
| ▸ | HRH2 | P25021 | 1/20 | 0.35 |
| ▸ | HRH1 | P35367 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.35 |
| ▸ | NPC1 | O15118 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12765239 | 1.00 | DPP4 (0.44) | DPP4DPP7CYP3A4CYP2D6SLC6A2 | |
| SCHEMBL12765238 | 1.00 | DPP4 (0.44) | DPP4DPP7CYP3A4CYP2D6SLC6A2 | |
| SCHEMBL12765247 | 0.89 | ALDH1A1 (0.44) | DPP4DPP7CHRM2CHRM4CHRM1 | |
| SCHEMBL12765248 | 0.89 | ALDH1A1 (0.44) | DPP4DPP7CHRM2CHRM4CHRM1 | |
| SCHEMBL13119145 | 0.89 | ALDH1A1 (0.41) | DPP4CHRM2CHRM4CHRM1HRH2 | |
| SCHEMBL25738639 | 0.84 | ARG1 (0.38) | ARG1HRH2HRH1 | |
| SCHEMBL13188562 | 0.82 | CHRM2 (0.42) | DPP4DPP7CYP3A4CYP2D6SLC6A2 | |
| SCHEMBL24456549 | 0.81 | ALDH1A1 (0.50) | DPP4DPP7ALDH1A1NPC1LMNA | |
| SCHEMBL24710038 | 0.81 | DPP4 (0.48) | DPP4DPP7CYP3A4CYP2D6SLC6A2 | |
| SCHEMBL25202270 | 0.80 | DPP4 (0.40) | DPP4DPP7CHRM2CHRM4CHRM1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3544975-B1 | DEGRADATION OF BRUTON'S TYROSINE KINASE (BTK) BY CONJUGATION OF BTK INHIBITORS WITH E3 LIGASE LIGAND AND USE | DANA FARBER CANCER INST INC (US) | 2022-01-05 | — | — | EP | disclosed |