Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | RECQL | P46063 | 1/20 | 0.34 |
| ▸ | PDK2 | Q15119 | 2/20 | 0.34 |
| ▸ | CNR1 | P21554 | 2/20 | 0.33 |
| ▸ | CNR2 | P34972 | 2/20 | 0.33 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.33 |
| ▸ | POLB | P06746 | 1/20 | 0.33 |
| ▸ | MPO | P05164 | 1/20 | 0.33 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.32 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.32 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.32 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.32 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.32 |
| ▸ | HDAC5 | Q9UQL6 | 1/20 | 0.32 |
| ▸ | FAAH | O00519 | 1/20 | 0.31 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.31 |
| ▸ | OXER1 | Q8TDS5 | 1/20 | 0.31 |
| ▸ | MTNR1A | P48039 | 1/20 | 0.31 |
| ▸ | NAMPT | P43490 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9363475 | 0.88 | LMNA (0.48) | LMNAALDH1A1PDK2CNR1CNR2 | |
| SCHEMBL12745317 | 0.79 | LMNA (0.44) | LMNAALDH1A1RECQLCNR1CNR2 | |
| SCHEMBL18555743 | 0.77 | KDM4E (0.44) | LMNAALDH1A1POLBHDAC3HDAC1 | |
| SCHEMBL7753090 | 0.77 | LMNA (0.57) | LMNAALDH1A1RECQLMCL1POLB | |
| SCHEMBL5909180 | 0.77 | LMNA (0.57) | LMNARECQLMCL1POLBHDAC3 | |
| SCHEMBL21078328 | 0.76 | LMNA (0.46) | LMNAALDH1A1PDK2CNR1CNR2 | |
| Hydrochloric Acid SCHEMBL375176 | 0.76 | KDM4E (0.43) | LMNAALDH1A1POLBHDAC3HDAC1 | |
| SCHEMBL14963638 | 0.75 | LMNA (0.50) | LMNAALDH1A1RECQLPDK2CNR1 | |
| SCHEMBL5909483 | 0.75 | HDAC3 (0.55) | LMNARECQLMCL1HDAC3HDAC1 | |
| SCHEMBL5909431 | 0.75 | HDAC3 (0.55) | LMNARECQLMCL1HDAC3HDAC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3793565-B1 | MCL-1 INHIBITORS | GILEAD SCIENCES INC (US) | 2022-01-05 | — | — | EP | disclosed |