Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SCN10A | Q9Y5Y9 | 4/20 | 0.48 |
| ▸ | SCN1A | P35498 | 1/20 | 0.45 |
| ▸ | SCN5A | Q14524 | 1/20 | 0.45 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.45 |
| ▸ | TYK2 | P29597 | 2/20 | 0.36 |
| ▸ | CHRNA7 | P36544 | 1/20 | 0.35 |
| ▸ | NPC1 | O15118 | 4/20 | 0.35 |
| ▸ | RAB9A | P51151 | 4/20 | 0.35 |
| ▸ | GAA | P10253 | 2/20 | 0.34 |
| ▸ | MITF | O75030 | 1/20 | 0.34 |
| ▸ | TP53 | P04637 | 1/20 | 0.34 |
| ▸ | THRB | P10828 | 1/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.34 |
| ▸ | JAK2 | O60674 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
| ▸ | HPGD | P15428 | 1/20 | 0.34 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.34 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.34 |
| ▸ | KIT | P10721 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2420059 | 0.87 | SCN10A (0.54) | SCN10ASCN1ASCN5ASCN9ATYK2 | |
| SCHEMBL2415208 | 0.85 | SCN10A (0.50) | SCN10ASCN1ASCN5ASCN9ATYK2 | |
| SCHEMBL2419090 | 0.81 | SCN10A (0.51) | SCN10ASCN1ASCN5ASCN9ATYK2 | |
| SCHEMBL2416261 | 0.79 | SCN10A (0.75) | SCN10ASCN1ASCN5ASCN9ATYK2 | |
| SCHEMBL2410050 | 0.79 | SCN10A (0.52) | SCN10ASCN1ASCN5ASCN9ACHRNA7 | |
| SCHEMBL2414736 | 0.78 | SCN10A (0.48) | SCN10ASCN1ASCN5ASCN9AGAA | |
| SCHEMBL2418091 | 0.78 | SCN10A (0.53) | SCN10ASCN1ASCN5ASCN9ATYK2 | |
| SCHEMBL2418806 | 0.77 | SCN10A (0.53) | SCN10ASCN1ASCN5ASCN9ANPC1 | |
| SCHEMBL2410516 | 0.76 | SCN10A (0.75) | SCN10ASCN1ASCN5ASCN9ANPC1 | |
| SCHEMBL2415948 | 0.76 | SCN10A (0.54) | SCN10ASCN1ASCN5ASCN9ACHRNA7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1945630-B1 | PYRAZINE DERIVATIVES AS SODIUM CHANNEL MODULATORS FOR THE TREATMENT OF PAIN | PFIZER LTD (GB) | 2011-09-21 | — | — | EP | disclosed |