Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK14 | Q16539 | 3/20 | 0.36 |
| ▸ | PPARA | Q07869 | 4/20 | 0.35 |
| ▸ | PPARG | P37231 | 3/20 | 0.35 |
| ▸ | PPARD | Q03181 | 2/20 | 0.35 |
| ▸ | DDR2 | Q16832 | 3/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.32 |
| ▸ | MAPT | P10636 | 2/20 | 0.32 |
| ▸ | TP53 | P04637 | 1/20 | 0.32 |
| ▸ | TSHR | P16473 | 1/20 | 0.32 |
| ▸ | NPC1 | O15118 | 1/20 | 0.32 |
| ▸ | LMNA | P02545 | 1/20 | 0.32 |
| ▸ | RAB9A | P51151 | 1/20 | 0.32 |
| ▸ | FGFR1 | P11362 | 2/20 | 0.32 |
| ▸ | KDR | P35968 | 2/20 | 0.32 |
| ▸ | POLB | P06746 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2413472 | 0.88 | MAPK14 (0.36) | MAPK14PPARAPPARGPPARDDDR2 | |
| SCHEMBL2417271 | 0.88 | PPARA (0.37) | MAPK14PPARAPPARGPPARDDDR2 | |
| SCHEMBL2408602 | 0.88 | MAPK14 (0.39) | MAPK14PPARAPPARGDDR2ALDH1A1 | |
| SCHEMBL2412840 | 0.86 | MAPK14 (0.36) | MAPK14PPARAPPARGPPARDDDR2 | |
| SCHEMBL2413999 | 0.85 | MAPK14 (0.41) | MAPK14PPARAPPARGPPARDDDR2 | |
| SCHEMBL2413912 | 0.82 | MAPK14 (0.37) | MAPK14PPARAPPARGPPARDDDR2 | |
| SCHEMBL2418172 | 0.82 | MAPK14 (0.39) | MAPK14PPARAPPARGDDR2L3MBTL1 | |
| SCHEMBL2414890 | 0.78 | MAPK14 (0.37) | MAPK14PPARAPPARDDDR2L3MBTL1 | |
| SCHEMBL14452324 | 0.76 | MAPK14 (0.39) | MAPK14PPARADDR2KDM4EL3MBTL1 | |
| SCHEMBL2420185 | 0.75 | PPARG (0.43) | PPARAPPARGPPARDSMN1; SMN2KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8026370-B2 | Peroxisome proliferator antagonist; hyperlipemia agents; arteriosclerosis; antiischemic agents | MITSUBISHI TANABE PHARMA CORPORATION (JP) | 2011-09-27 | — | — | US | claimed |