Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DHODH | Q02127 | 10/20 | 0.58 |
| ▸ | PTGFR | P43088 | 6/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.45 |
| ▸ | XDH | P47989 | 1/20 | 0.45 |
| ▸ | PIN1 | Q13526 | 1/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.43 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.43 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.43 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.43 |
| ▸ | HTT | P42858 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2372504 | 0.83 | DHODH (0.69) | DHODHPTGFRALDH1A1SMN1; SMN2KDM4E | |
| SCHEMBL2417777 | 0.83 | DHODH (0.59) | DHODHPTGFRALDH1A1SMN1; SMN2XDH | |
| SCHEMBL2373344 | 0.83 | DHODH (0.82) | DHODHPTGFR | |
| SCHEMBL2372830 | 0.81 | DHODH (0.69) | DHODHPTGFRALDH1A1SMN1; SMN2XDH | |
| SCHEMBL2372855 | 0.81 | DHODH (0.71) | DHODHPTGFRKMT2A | |
| SCHEMBL2373037 | 0.80 | DHODH (0.70) | DHODHSMN1; SMN2KDM4ECYP1A2CYP2C9 | |
| SCHEMBL2372739 | 0.80 | DHODH (0.71) | DHODH | |
| SCHEMBL2373103 | 0.80 | DHODH (0.70) | DHODHPTGFRALDH1A1SMN1; SMN2KDM4E | |
| SCHEMBL2373336 | 0.79 | DHODH (0.62) | DHODHPTGFR | |
| SCHEMBL2373114 | 0.79 | DHODH (0.62) | DHODHPTGFR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011119694-A1 | TRPV4 ANTAGONISTS | GLAXOSMITHKLINE LLC (US) | 2011-09-29 | — | — | WO | disclosed |
| WO-2011119694-A1 | TRPV4 ANTAGONISTS | GLAXOSMITHKLINE LLC (US) | 2011-09-29 | — | — | WO | disclosed |