Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GAA | P10253 | 1/20 | 0.48 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.48 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.48 |
| ▸ | NPC1 | O15118 | 3/20 | 0.44 |
| ▸ | RAB9A | P51151 | 3/20 | 0.44 |
| ▸ | CNR2 | P34972 | 3/20 | 0.38 |
| ▸ | CNR1 | P21554 | 2/20 | 0.38 |
| ▸ | SLC2A1 | P11166 | 1/20 | 0.37 |
| ▸ | EGFR | P00533 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 2/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | CTSD | P07339 | 1/20 | 0.35 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.35 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2421361 | 0.90 | MEN1 (0.42) | GAATDP1L3MBTL1NPC1RAB9A | |
| SCHEMBL2418389 | 0.85 | HPGD (0.39) | GAANPC1RAB9AEGFRMAPT | |
| SCHEMBL2949995 | 0.77 | MAPT (0.38) | GAANPC1RAB9AEGFRMAPT | |
| SCHEMBL2417802 | 0.77 | GAA (0.42) | GAATDP1L3MBTL1NPC1RAB9A | |
| SCHEMBL2414362 | 0.76 | GAA (0.41) | GAATDP1L3MBTL1NPC1RAB9A | |
| SCHEMBL2421608 | 0.71 | S1PR1 (0.45) | GAATDP1L3MBTL1SLC2A1ALDH1A1 | |
| SCHEMBL2417097 | 0.71 | S1PR1 (0.43) | GAATDP1L3MBTL1NPC1RAB9A | |
| SCHEMBL7642915 | 0.71 | MAPT (0.66) | L3MBTL1NPC1RAB9AEGFRMAPT | |
| SCHEMBL636533 | 0.70 | NPC1 (0.62) | L3MBTL1NPC1RAB9AMAPTALDH1A1 | |
| SCHEMBL8749413 | 0.69 | GAA (0.55) | GAATDP1L3MBTL1CNR2CNR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8026255-B2 | Substituted piperidines as somatostatin receptor subtype 5 (SSTR5) antagonists | HOFFMAN-LA ROCHE INC. (US) | 2011-09-27 | — | — | US | disclosed |