Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GAA | P10253 | 3/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.42 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.39 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.37 |
| ▸ | RAB9A | P51151 | 3/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.35 |
| ▸ | G6PD | P11413 | 1/20 | 0.35 |
| ▸ | GRM5 | P41594 | 1/20 | 0.34 |
| ▸ | SLC2A1 | P11166 | 1/20 | 0.34 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.34 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | DHFR | P00374 | 1/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.33 |
| ▸ | MAPT | P10636 | 3/20 | 0.33 |
| ▸ | GLA | P06280 | 2/20 | 0.33 |
| ▸ | NPC1 | O15118 | 2/20 | 0.33 |
| ▸ | HPGD | P15428 | 2/20 | 0.33 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2414362 | 0.87 | GAA (0.41) | GAAALDH1A1S1PR1CYP2A6RAB9A | |
| SCHEMBL2421361 | 0.86 | MEN1 (0.42) | GAAALDH1A1S1PR1RAB9APOLB | |
| SCHEMBL2417097 | 0.80 | S1PR1 (0.43) | GAAALDH1A1S1PR1RAB9APOLB | |
| SCHEMBL2421608 | 0.80 | S1PR1 (0.45) | GAAALDH1A1S1PR1POLBG6PD | |
| SCHEMBL2424610 | 0.77 | L3MBTL1 (0.40) | GAAALDH1A1S1PR1CYP2A6RAB9A | |
| SCHEMBL2417832 | 0.77 | GAA (0.48) | GAAALDH1A1S1PR1RAB9ASLC2A1 | |
| SCHEMBL2424612 | 0.75 | GAA (0.41) | GAAALDH1A1S1PR1CYP2A6RAB9A | |
| SCHEMBL2418389 | 0.74 | HPGD (0.39) | GAAALDH1A1S1PR1RAB9APOLB | |
| SCHEMBL15780759 | 0.73 | CYP2A6 (0.53) | ALDH1A1CYP2A6RAB9AL3MBTL1KMT2A | |
| SCHEMBL2599676 | 0.70 | ALDH1A1 (0.35) | GAAALDH1A1RAB9AKMT2AKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8026255-B2 | Substituted piperidines as somatostatin receptor subtype 5 (SSTR5) antagonists | HOFFMAN-LA ROCHE INC. (US) | 2011-09-27 | — | — | US | disclosed |