SCHEMBL2418565

SCHEMBL2418565

Clc1c(C(Cl)Cl)cccc1C(Cl)(Cl)Cl

nearest known ligand 0.43

Predicted protein targets (top 17)

geneUniProtsupporting neighboursconfidence
P2RX7 Q99572 1/20 0.43
CYP3A4 P08684 3/20 0.36
CYP1A2 P05177 2/20 0.36
CYP2D6 P10635 1/20 0.36
NFKB1 P19838 1/20 0.36
PNMT P11086 1/20 0.36
ALDH1A1 P00352 2/20 0.35
LMNA P02545 1/20 0.35
GLA P06280 1/20 0.35
CYP2A6 P11509 1/20 0.33
TSHR P16473 3/20 0.32
MAPK1 P28482 1/20 0.31
TDP1 Q9NUW8 1/20 0.31
MEN1 O00255 1/20 0.30
KMT2A Q03164 1/20 0.30
IDO1 P14902 1/20 0.30
TDO2 P48775 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL29522913 0.79 TSHR (0.36) P2RX7CYP3A4ALDH1A1LMNATSHR
SCHEMBL1845725 0.79 TSHR (0.36) P2RX7CYP3A4ALDH1A1LMNATSHR
SCHEMBL11549028 0.78 TSHR (0.40) P2RX7CYP3A4CYP1A2CYP2D6NFKB1
SCHEMBL10968544 0.77 IDO1 (0.36) P2RX7IDO1TDO2
SCHEMBL11173889 0.77 P2RX7 (0.34) P2RX7
SCHEMBL1872442 0.77 CYP1A2 (0.58) CYP3A4CYP1A2CYP2D6NFKB1PNMT
SCHEMBL2262591 0.74 TSHR (0.46) CYP3A4CYP1A2CYP2D6NFKB1PNMT
SCHEMBL10493638 0.70 TSHR (0.36) P2RX7ALDH1A1TSHR
SCHEMBL10968761 0.70 CYP3A4 (0.35) CYP3A4TSHRMAPK1TDP1
SCHEMBL10893212 0.68 P2RX7 (0.50) P2RX7ALDH1A1TDP1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 41 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0132868-A1 Alpha-halogenated aromatic compounds as photoinitiators STAUFFER CHEMICAL COMPANY (US) 1985-02-13 EP claimed
JP-53121733-A None JP disclosed
US-20240279396-A1 CYCLIC OLIGO(ARYLENE ETHER)S, PROCESSES FOR THEIR PREPARATION AND THEIR USE SOLVAY SA (BE) 2024-08-22 US disclosed
EP-4352045-A1 CYCLIC OLIGO(ARYLENE ETHER)S, PROCESSES FOR THEIR PREPARATION AND THEIR USE SYENSQO SA (BE) 2024-04-17 EP disclosed
WO-2022258332-A1 CYCLIC OLIGO(ARYLENE ETHER)S, PROCESSES FOR THEIR PREPARATION AND THEIR USE SOLVAY SA (BE) 2022-12-15 WO disclosed
CN-110603300-B Roller and method for manufacturing roller 琳得科株式会社 2021-10-15 CN disclosed
CN-110325609-B Roller and method for manufacturing roller 琳得科株式会社 2021-08-17 CN disclosed
CN-107250306-B Coating film protective film 琳得科株式会社 2020-10-13 CN disclosed
CN-110603300-A Roller and method for manufacturing roller 琳得科株式会社 2019-12-20 CN disclosed
CN-105424860-A Liquid chromatographic analysis method of alpha, alpha, alpha, alpha', alpha', alpha'-hexachloro-m-xylene SHANDONG KAISHENG NEW MATERIALS CO LTD 2016-03-23 CN disclosed
JP-S53121733-A PREPARATION OF MIXTURE OF TERE AND ISO-PHTHALIC ACID CHLORIDES SHIN ETSU CHEM CO LTD 1978-10-24 JP disclosed
US-4091017-A FRIEDEL-CRAFTS CATALYSTS, HYDROLYSIS DYNAMIT NOBEL AKTIENGESELLSCHAFT (DT) 1978-05-23 US disclosed
US-4078007-A HYDROFLUORIC ACID, ANTIMONY HALIDES HALOCARBON PRODUCTS CORPORATION (US) 1978-03-07 US disclosed
US-4075238-A Polyhalobenzylic disulfooxonium compounds HOOKER CHEMICALS & PLASTICS CORPORATION (US) 1978-02-21 US disclosed
US-4048033-A FROM THE PARTIALLY CHLORINATED METHYLBENZENE AND CHLORINE, ULTRAVIOLET RADIATION MITSUBISHI GAS CHEMICAL COMPANY, INC. (JA) 1977-09-13 US disclosed
US-4029560-A CHLORINATION OF XYLENE, ULTRAVIOLET RADIATION MITSUBISHI GAS CHEMICAL COMPANY, INC. (JA) 1977-06-14 US disclosed
US-4029592-A ANHYDRIDED, HALOGENATED HYDROCARBON, TARRY BY-PRODUCT SUPPRESSANTS STANDARD OIL COMPANY (INDIANA) (US) 1977-06-14 US disclosed
US-3975448-A THERMAL STABILITY, CHEMICAL RESISTANCE TESSENDERLO CHEMIE S.A. (BE) 1976-08-17 US disclosed
US-3960900-A POLYBUTENE, MALEIC ANHYDRIDE STANDARD OIL COMPANY (US) 1976-06-01 US disclosed
US-3942996-A Radiation sensitive recording material AGFA-GEVAERT AKTIENGESELLSCHAFT (DT) 1976-03-09 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20240279396-A1 CYCLIC OLIGO(ARYLENE ETHER)S, PROCESSES FOR THEIR PREPARATION AND THEIR USE PDXK, HCK, DEK P2RX7 404/4885CYP3A4 199/4885CYP1A2 172/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.