Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LIMK1 | P53667 | 1/20 | 0.41 |
| ▸ | MAP4K3 | Q8IVH8 | 2/20 | 0.40 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.40 |
| ▸ | GCK | P35557 | 1/20 | 0.40 |
| ▸ | MAP4K1 | Q92918 | 1/20 | 0.40 |
| ▸ | MAP4K5 | Q9Y4K4 | 1/20 | 0.40 |
| ▸ | SLC6A2 | P23975 | 6/20 | 0.37 |
| ▸ | SLC6A4 | P31645 | 6/20 | 0.37 |
| ▸ | SLC6A3 | Q01959 | 6/20 | 0.37 |
| ▸ | KDR | P35968 | 1/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.35 |
| ▸ | FLT3 | P36888 | 2/20 | 0.34 |
| ▸ | MKNK1 | Q9BUB5 | 1/20 | 0.34 |
| ▸ | KIT | P10721 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24188228 | 0.77 | ALDH1A1 (0.42) | SLC6A2SLC6A4SLC6A3KDR | |
| SCHEMBL24188525 | 0.75 | MAPT (0.44) | MAP4K3MAP4K4GCKMAP4K1MAP4K5 | |
| SCHEMBL24188234 | 0.72 | CHRNB2 (0.46) | LIMK1 | |
| SCHEMBL24188279 | 0.72 | TLR9 (0.41) | KDR | |
| SCHEMBL24212898 | 0.72 | SLC6A2 (0.41) | SLC6A2SLC6A4SLC6A3KDRMKNK1 | |
| SCHEMBL9906381 | 0.71 | CCNE1 (0.35) | — | |
| SCHEMBL24212826 | 0.71 | MCHR1 (0.37) | MKNK1 | |
| SCHEMBL24188225 | 0.71 | APP (0.46) | — | |
| SCHEMBL1474932 | 0.70 | CSNK2A1 (0.48) | MKNK1 | |
| SCHEMBL4875916 | 0.69 | SLC6A2 (0.58) | SLC6A2SLC6A4SLC6A3MKNK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022010537-A1 | GAS41 INHIBITORS AND METHODS OF USE THEREOF | THE REGENTS OF THE UNIVERSITY OF MICHIGAN (US) | 2022-01-13 | — | — | WO | disclosed |