Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDCD1 | Q15116 | 2/20 | 0.49 |
| ▸ | CD274 | Q9NZQ7 | 2/20 | 0.49 |
| ▸ | HTR7 | P34969 | 2/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.45 |
| ▸ | NPC1 | O15118 | 2/20 | 0.45 |
| ▸ | RAB9A | P51151 | 2/20 | 0.45 |
| ▸ | GPR55 | Q9Y2T6 | 1/20 | 0.45 |
| ▸ | PTGES | O14684 | 2/20 | 0.42 |
| ▸ | GUSB | P08236 | 1/20 | 0.41 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.40 |
| ▸ | MGAM | O43451 | 1/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
| ▸ | SI | P14410 | 1/20 | 0.40 |
| ▸ | MGAM2 | Q2M2H8 | 1/20 | 0.40 |
| ▸ | DCUN1D1 | Q96GG9 | 2/20 | 0.40 |
| ▸ | APOBEC3G | Q9HC16 | 1/20 | 0.40 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.40 |
| ▸ | PNMT | P11086 | 1/20 | 0.37 |
| ▸ | TP53 | P04637 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24187953 | 0.88 | PDCD1 (0.62) | PDCD1CD274HTR7KDM4EALDH1A1 | |
| SCHEMBL24188218 | 0.82 | PDCD1 (0.49) | PDCD1CD274HTR7ALDH1A1NPC1 | |
| SCHEMBL31288988 | 0.80 | ALDH1A1 (0.49) | PDCD1CD274KDM4EALDH1A1NPC1 | |
| SCHEMBL8319716 | 0.78 | PDCD1 (0.53) | PDCD1CD274HTR7KDM4EALDH1A1 | |
| SCHEMBL24188029 | 0.78 | ADRA2A (0.41) | PDCD1CD274HTR7CYP1A2CYP2D6 | |
| SCHEMBL24187984 | 0.77 | PDCD1 (0.60) | PDCD1CD274HTR7KDM4EALDH1A1 | |
| Hydrochloric Acid SCHEMBL4760135 | 0.77 | PDCD1 (0.52) | PDCD1CD274HTR7KDM4EALDH1A1 | |
| SCHEMBL19549728 | 0.77 | CD274 (0.81) | PDCD1CD274HTR7CYP1A2CYP3A4 | |
| SCHEMBL24188144 | 0.72 | GUSB (0.47) | KDM4EALDH1A1NPC1RAB9AGPR55 | |
| SCHEMBL24187941 | 0.71 | PDCD1 (0.62) | PDCD1CD274HTR7KDM4EALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20220009935-A1 | INHIBITORS OF GLI1 AS THERAPEUTIC AGENTS | NEW YORK UNIVERSITY | 2022-01-13 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20220009935-A1 | INHIBITORS OF GLI1 AS THERAPEUTIC AGENTS | GLI1, GLI2, SHH | PDCD1 3044/4885CD274 4270/4885HTR7 2809/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.