Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 2/20 | 0.40 |
| ▸ | GALR2 | O43603 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.40 |
| ▸ | ESPL1 | Q14674 | 1/20 | 0.40 |
| ▸ | ATM | Q13315 | 1/20 | 0.40 |
| ▸ | HCAR3 | P49019 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.39 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.37 |
| ▸ | VCAM1 | P19320 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 6/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.36 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.35 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.35 |
| ▸ | HPGD | P15428 | 1/20 | 0.35 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.35 |
| ▸ | RAB9A | P51151 | 2/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.35 |
| ▸ | NPC1 | O15118 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25859507 | 0.95 | POLB (0.39) | POLBGALR2LMNATDP1ESPL1 | |
| SCHEMBL25859572 | 0.79 | HCAR3 (0.41) | POLBGALR2LMNATDP1HCAR3 | |
| SCHEMBL23418074 | 0.78 | HCAR3 (0.47) | POLBGALR2LMNATDP1ESPL1 | |
| SCHEMBL24933592 | 0.76 | ATM (0.36) | LMNATDP1ESPL1ATMALDH1A1 | |
| SCHEMBL19239593 | 0.74 | ALDH1A1 (0.42) | TDP1ESPL1ATMHCAR3ALDH1A1 | |
| SCHEMBL8270845 | 0.73 | TDP1 (0.42) | POLBLMNATDP1ESPL1ATM | |
| SCHEMBL20750204 | 0.73 | TDP1 (0.42) | POLBGALR2LMNATDP1ESPL1 | |
| SCHEMBL22025579 | 0.72 | MAPT (0.50) | LMNATDP1ALDH1A1HTTMAPT | |
| SCHEMBL3413676 | 0.72 | MAPT (0.54) | POLBLMNATDP1ALDH1A1HIF1A | |
| SCHEMBL9901830 | 0.72 | TDP1 (0.47) | POLBLMNATDP1ESPL1ATM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022011274-A1 | SUBSTITUTED 1,6-NAPHTHYRIDINE INHIBITORS OF CDK5 | GOLDFINCH BIO, INC. (US) | 2022-01-13 | — | — | WO | disclosed |