Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.56 |
| ▸ | CASP6 | P55212 | 1/20 | 0.49 |
| ▸ | GFER | P55789 | 1/20 | 0.49 |
| ▸ | NCF1 | P14598 | 2/20 | 0.44 |
| ▸ | MAPT | P10636 | 2/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.43 |
| ▸ | GPR174 | Q9BXC1 | 2/20 | 0.42 |
| ▸ | TP53 | P04637 | 1/20 | 0.41 |
| ▸ | USP2 | O75604 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 3/20 | 0.41 |
| ▸ | TSHR | P16473 | 1/20 | 0.40 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
| ▸ | CLK1 | P49759 | 1/20 | 0.40 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | MAOB | P27338 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3315976 | 0.80 | ALDH1A1 (0.60) | ALDH1A1CASP6GFERNCF1MAPT | |
| SCHEMBL10375746 | 0.78 | GFER (0.58) | ALDH1A1CASP6GFERNCF1MAPT | |
| SCHEMBL3099621 | 0.78 | GFER (0.58) | ALDH1A1CASP6GFERNCF1MAPT | |
| SCHEMBL3312656 | 0.76 | ALDH1A1 (0.72) | ALDH1A1CASP6GFERNCF1MAPT | |
| SCHEMBL13419194 | 0.76 | MAPT (0.54) | ALDH1A1MAPTL3MBTL1GPR174LMNA | |
| SCHEMBL24196221 | 0.75 | MAPT (0.46) | ALDH1A1MAPTL3MBTL1TP53USP2 | |
| SCHEMBL5988851 | 0.75 | ALDH1A1 (0.65) | ALDH1A1CASP6GFERNCF1MAPT | |
| SCHEMBL3311256 | 0.74 | ALDH1A1 (0.54) | ALDH1A1CASP6GFERNCF1MAPT | |
| SCHEMBL18711276 | 0.74 | TP53 (0.56) | ALDH1A1MAPTL3MBTL1GPR174TP53 | |
| SCHEMBL3314619 | 0.73 | ALDH1A1 (0.53) | ALDH1A1CASP6GFERNCF1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022011274-A1 | SUBSTITUTED 1,6-NAPHTHYRIDINE INHIBITORS OF CDK5 | GOLDFINCH BIO, INC. (US) | 2022-01-13 | — | — | WO | disclosed |