Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.54 |
| ▸ | USP2 | O75604 | 1/20 | 0.47 |
| ▸ | CASP6 | P55212 | 1/20 | 0.47 |
| ▸ | GFER | P55789 | 1/20 | 0.47 |
| ▸ | LMNA | P02545 | 4/20 | 0.45 |
| ▸ | MAPT | P10636 | 2/20 | 0.45 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.44 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.44 |
| ▸ | TGFBR1 | P36897 | 1/20 | 0.44 |
| ▸ | ACVR1 | Q04771 | 1/20 | 0.44 |
| ▸ | HTT | P42858 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
| ▸ | NCF1 | P14598 | 2/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3316445 | 0.89 | ALDH1A1 (0.49) | ALDH1A1USP2CASP6GFERLMNA | |
| SCHEMBL3309920 | 0.85 | ALDH1A1 (0.55) | ALDH1A1USP2CASP6GFERLMNA | |
| SCHEMBL3315976 | 0.84 | ALDH1A1 (0.60) | ALDH1A1CASP6GFERLMNAMAPT | |
| SCHEMBL3316035 | 0.82 | LMNA (0.49) | ALDH1A1USP2CASP6GFERLMNA | |
| SCHEMBL3309164 | 0.79 | MAPT (0.49) | ALDH1A1LMNAMAPTMAPK1HTT | |
| SCHEMBL2205218 | 0.77 | TGFBR1 (0.41) | ALDH1A1LMNAMAPTNPSR1MAPK1 | |
| SCHEMBL3312656 | 0.77 | ALDH1A1 (0.72) | ALDH1A1CASP6GFERLMNAMAPT | |
| SCHEMBL3347067 | 0.76 | MEN1 (0.35) | ALDH1A1GFERLMNAMAPTNPSR1 | |
| SCHEMBL24196352 | 0.74 | ALDH1A1 (0.56) | ALDH1A1USP2CASP6GFERLMNA | |
| SCHEMBL17021420 | 0.73 | MAPT (0.41) | ALDH1A1LMNAMAPTNPSR1MAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20100105655-A1 | NOVEL COMPOUNDS 515 | ASTRAZENECA AB | 2010-04-29 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100105655-A1 | NOVEL COMPOUNDS 515 | TYMS, ABCG2, UMPS | ALDH1A1 649/4885USP2 4534/4885CASP6 2309/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.