⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2411834 | 0.93 | — | — | |
| SCHEMBL4924587 | 0.85 | — | — | |
| SCHEMBL3127463 | 0.81 | SMN1; SMN2 (0.33) | — | |
| SCHEMBL9538357 | 0.80 | — | — | |
| SCHEMBL7217104 | 0.80 | GBA1 (0.36) | — | |
| SCHEMBL4918129 | 0.77 | — | — | |
| SCHEMBL8199098 | 0.77 | — | — | |
| SCHEMBL3170029 | 0.76 | LMNA (0.32) | — | |
| SCHEMBL1827552 | 0.75 | — | — | |
| SCHEMBL4917500 | 0.74 | SMN1; SMN2 (0.34) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 39 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20190127413-A1 | Compositions and Methods for Non-Toxic Delivery of Antiprogestins | ALLERGAN PHARMACEUTICALS INTERNATIONAL LIMITED (IE) | 2019-05-02 | — | — | US | claimed |
| EP-2550288-A1 | COMPOSITIONS AND METHODS FOR NON-TOXIC DELIVERY OF ANTIPROGESTINS | Repros Therapeutics Inc. (US) | 2013-01-30 | — | — | EP | claimed |
| US-20130018027-A1 | COMPOSITIONS AND METHODS FOR NON-TOXIC DELIVERY OF ANTIPROGESTINS | REPROS THERAPEUTICS INC. (US) | 2013-01-17 | — | — | US | claimed |
| WO-2011119194-A1 | COMPOSITIONS AND METHODS FOR NON-TOXIC DELIVERY OF ANTIPROGESTINS | REPROS THERAPEUTICS INC. (US) | 2011-09-29 | — | — | WO | claimed |
| CN-109715617-B | Dimethoxyphenyl-substituted indole compounds as inhibitors of TLR7, TLR8 or TLR9 | 百时美施贵宝公司 | 2022-04-19 | — | — | CN | disclosed |
| EP-3865502-A1 | COMPOSITIONS AND METHODS FOR NON-TOXIC DELIVERY OF CDB-2914 | Allergan Pharmaceuticals International Limited (IE) | 2021-08-18 | — | — | EP | disclosed |
| US-20190127413-A1 | Compositions and Methods for Non-Toxic Delivery of Antiprogestins | ALLERGAN PHARMACEUTICALS INTERNATIONAL LIMITED (IE) | 2019-05-02 | — | — | US | disclosed |
| EP-2550288-A1 | COMPOSITIONS AND METHODS FOR NON-TOXIC DELIVERY OF ANTIPROGESTINS | Repros Therapeutics Inc. (US) | 2013-01-30 | — | — | EP | disclosed |
| US-20130018027-A1 | COMPOSITIONS AND METHODS FOR NON-TOXIC DELIVERY OF ANTIPROGESTINS | REPROS THERAPEUTICS INC. (US) | 2013-01-17 | — | — | US | disclosed |
| EP-1854792-B1 | 1-(2H)-ISOQUINOLONE DERIVATIVE | CHUGAI PHARMACEUTICAL CO LTD (JP) | 2012-12-26 | — | — | EP | disclosed |
| WO-2011119194-A1 | COMPOSITIONS AND METHODS FOR NON-TOXIC DELIVERY OF ANTIPROGESTINS | REPROS THERAPEUTICS INC. (US) | 2011-09-29 | — | — | WO | disclosed |
| US-7820693-B2 | 1-(2H)-isoquinolone derivative | CHUGAI SEIYAKU KABUSHIKI KAISHA (JP) | 2010-10-26 | — | — | US | disclosed |
| US-4092318-A | HYPOTENSIVES | E. R. SQUIBB & SONS, INC. (US) | 1978-05-30 | — | — | US | disclosed |
| US-4082773-A | TRICYCLIC TETRAHYDRO NAPHTHALENEOLS AND RELATED COMPOUNDS | E. R. SQUIBB & SONS, INC. (US) | 1978-04-04 | — | — | US | disclosed |
| US-4053596-A | HYPOTENSIVE AGENTS | E. R. SQUIBB & SONS, INC. (US) | 1977-10-11 | — | — | US | disclosed |
| US-4044040-A | HYPERTENSIVE AGENTS | E. R. SQUIBB & SONS, INC. (US) | 1977-08-23 | — | — | US | disclosed |
| US-3984419-A | HYPOTENSIVES | E. R. SQUIBB & SONS, INC. (US) | 1976-10-05 | — | — | US | disclosed |
| US-3982021-A | Compositions for the treatment of coronary diseases containing tetrahydronaphthyloxy-aminopropanols | E. R. SQUIBB & SONS, INC. (US) | 1976-09-21 | — | — | US | disclosed |
| US-3943149-A | HYPOCHOLESTEREMIC, ANTIINFLAMMATORY | E. R. SQUIBB & SONS, INC. (US) | 1976-03-09 | — | — | US | disclosed |
| US-3935267-A | CARDIOVASCULAR DISORDERS | E. R. SQUIBB & SONS, INC. (US) | 1976-01-27 | — | — | US | disclosed |