Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 9/20 | 0.39 |
| ▸ | ABL1 | P00519 | 3/20 | 0.39 |
| ▸ | ERBB2 | P04626 | 2/20 | 0.39 |
| ▸ | MAP4K4 | O95819 | 2/20 | 0.39 |
| ▸ | PIM1 | P11309 | 2/20 | 0.39 |
| ▸ | MAP4K2 | Q12851 | 2/20 | 0.39 |
| ▸ | DYRK1A | Q13627 | 2/20 | 0.39 |
| ▸ | PIM3 | Q86V86 | 2/20 | 0.39 |
| ▸ | AURKB | Q96GD4 | 2/20 | 0.39 |
| ▸ | CLK4 | Q9HAZ1 | 2/20 | 0.39 |
| ▸ | DAPK3 | O43293 | 1/20 | 0.39 |
| ▸ | PRKACA | P17612 | 1/20 | 0.39 |
| ▸ | LTK | P29376 | 1/20 | 0.39 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.39 |
| ▸ | CSNK1A1 | P48729 | 1/20 | 0.39 |
| ▸ | RPS6KA3 | P51812 | 1/20 | 0.39 |
| ▸ | LIMK1 | P53667 | 1/20 | 0.39 |
| ▸ | MAP2K1 | Q02750 | 1/20 | 0.39 |
| ▸ | ACVR1 | Q04771 | 1/20 | 0.39 |
| ▸ | TYRO3 | Q06418 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24197038 | 0.74 | ALDH1A1 (0.52) | MAPK1MEN1GAAMAPTRAB9A | |
| SCHEMBL20925388 | 0.72 | CCNC (0.44) | EGFRABL1AURKBTTBK1SRC | |
| SCHEMBL13821142 | 0.70 | ABL1 (0.50) | EGFRABL1TTBK1TTBK2MAPK1 | |
| SCHEMBL7098162 | 0.69 | ALDH1A1 (0.56) | IDH1MEN1MAPTKMT2ALMNA | |
| SCHEMBL18696318 | 0.66 | TTBK1 (0.50) | ABL1TTBK1TTBK2 | |
| SCHEMBL18696319 | 0.66 | ABL1 (0.50) | ABL1TTBK1TTBK2 | |
| SCHEMBL20925539 | 0.65 | TTBK1 (0.44) | EGFRDYRK1ADYRK1BTTBK1 | |
| SCHEMBL18696264 | 0.63 | TTBK1 (0.49) | ABL1TTBK1TTBK2 | |
| SCHEMBL24197158 | 0.61 | HTT (0.56) | EGFRMAPK1MEN1RAB9AKMT2A | |
| SCHEMBL4734704 | 0.61 | EGFR (0.58) | EGFRABL1ERBB2MAP4K4PIM1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022011171-A1 | NOVEL COMPOUNDS AND METHODS FOR INCREASING KLOTHO GENE EXPRESSION | KLOTHO THERAPEUTICS, INC. (US) | 2022-01-13 | — | — | WO | disclosed |