Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.52 |
| ▸ | MAPT | P10636 | 6/20 | 0.52 |
| ▸ | SMN1; SMN2 | Q16637 | 6/20 | 0.52 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.52 |
| ▸ | RAB9A | P51151 | 4/20 | 0.52 |
| ▸ | HPGD | P15428 | 4/20 | 0.52 |
| ▸ | NPC1 | O15118 | 3/20 | 0.52 |
| ▸ | MEN1 | O00255 | 2/20 | 0.52 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.52 |
| ▸ | HTT | P42858 | 4/20 | 0.51 |
| ▸ | LMNA | P02545 | 4/20 | 0.51 |
| ▸ | GALR3 | O60755 | 1/20 | 0.51 |
| ▸ | GAA | P10253 | 1/20 | 0.51 |
| ▸ | TP53 | P04637 | 4/20 | 0.48 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.48 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.44 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.43 |
| ▸ | TSHR | P16473 | 1/20 | 0.43 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24196760 | 0.82 | ALDH1A1 (0.52) | ALDH1A1MAPTSMN1; SMN2KDM4ERAB9A | |
| SCHEMBL24197032 | 0.79 | ALDH1A1 (0.49) | ALDH1A1MAPTSMN1; SMN2KDM4ERAB9A | |
| SCHEMBL24197136 | 0.74 | EGFR (0.39) | MAPTSMN1; SMN2KDM4ERAB9AMEN1 | |
| SCHEMBL20925388 | 0.70 | CCNC (0.44) | ALDH1A1MAPTHPGDMEN1KMT2A | |
| SCHEMBL26255159 | 0.69 | MAPT (0.64) | ALDH1A1MAPTSMN1; SMN2KDM4ERAB9A | |
| SCHEMBL13821142 | 0.68 | ABL1 (0.50) | HTTLMNAMAPK1 | |
| SCHEMBL26255153 | 0.68 | ALDH1A1 (0.60) | ALDH1A1MAPTSMN1; SMN2KDM4ERAB9A | |
| SCHEMBL24196743 | 0.68 | ALDH1A1 (0.51) | ALDH1A1MAPTSMN1; SMN2KDM4ERAB9A | |
| SCHEMBL27371685 | 0.68 | MAPT (0.62) | ALDH1A1MAPTSMN1; SMN2KDM4ERAB9A | |
| SCHEMBL26255168 | 0.67 | KDM4E (0.98) | ALDH1A1MAPTSMN1; SMN2KDM4ERAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022011171-A1 | NOVEL COMPOUNDS AND METHODS FOR INCREASING KLOTHO GENE EXPRESSION | KLOTHO THERAPEUTICS, INC. (US) | 2022-01-13 | — | — | WO | disclosed |