SCHEMBL24197271

SCHEMBL24197271

Cc1cnc(N2CC3CNCC3C2)nc1

nearest known ligand 0.49

Predicted protein targets (top 7)

geneUniProtsupporting neighboursconfidence
BPTF Q12830 1/20 0.43
CHRNA4 P43681 10/20 0.42
CHRNB2 P17787 9/20 0.42
CHRNA7 P36544 3/20 0.42
CHRNB4 P30926 6/20 0.40
CHRNA3 P32297 6/20 0.40
GPR119 Q8TDV5 1/20 0.38

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL27366426 0.80 ACACB (0.33) CHRNA4CHRNB2CHRNB4CHRNA3GPR119
SCHEMBL22737347 0.79 CHRNA7 (0.43) CHRNA4CHRNB2CHRNA7CHRNB4CHRNA3
SCHEMBL27363075 0.79 CHRNA7 (0.43) CHRNA4CHRNB2CHRNA7CHRNB4CHRNA3
SCHEMBL29367080 0.79 BPTF (0.52) BPTFCHRNA4CHRNB2CHRNA7CHRNB4
SCHEMBL11922742 0.77 CHRNB2 (0.40) BPTFCHRNA4CHRNB2CHRNA7CHRNB4
SCHEMBL14845792 0.77 CHRNA7 (0.47) BPTFCHRNA4CHRNB2CHRNA7GPR119
SCHEMBL25389142 0.77 ACACB (0.46) BPTFCHRNA4CHRNB2CHRNA7
Hydrochloric Acid SCHEMBL29363810 0.77 CHRNA7 (0.53) BPTFCHRNA4CHRNB2CHRNA7CHRNB4
SCHEMBL16472351 0.76 ACACB (0.39) GPR119
SCHEMBL17972943 0.76 TSHR (0.39) GPR119

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-4180432-A1 COMPOUND HAVING BTK KINASE DEGRADING ACTIVITY, AND PREPARATION METHOD AND PHARMACEUTICAL USE THEREFOR Sichuan Haisco Pharmaceutical Co., Ltd. (CN) 2023-05-17 EP disclosed
WO-2022007824-A1 COMPOUND HAVING BTK KINASE DEGRADING ACTIVITY, AND PREPARATION METHOD AND PHARMACEUTICAL USE THEREFOR 四川海思科制药有限公司 2022-01-13 WO disclosed